POSTPONED – Dynamic organelle shape and function during herpesvirus infection
Research in the Cristea laboratory focuses on characterizing mechanisms of cellular defense against viruses, as well as mechanisms used by viruses to manipulate these critical cellular processes. Towards these goals, her lab has promoted the integration of virology with proteomics and bioinformatics. The development of methods for studying virus-host protein interactions in space and time during the progression of an infection has allowed her group to bridge developments in mass spectrometry to important findings in virology. For example, her laboratory has contributed to the emergence of the research field of nuclear DNA sensing in immune response and has discovered sirtuins as broad-spectrum antiviral factors.
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