POSTPONED – Stem cells growing up and finding their niche
Stem cells have the ability to self renew or differentiate and this is controlled by the environment or the niche. By understanding the RNA expression and chromatin structure of endothelial cells that stimulate blood stem cells, we have been able to fully reconstruct an ectopic stem cell niche in vivo. Blood stem cells are attracted to the ectopic sites and divide. Stem cells expand in clones and we have developed a system to barcode each stem cell and follow cell fate. Mutations in epigenetic regulators associated with aging establish clonal dominance in the blood. Distinct mechanisms of clonal dominance occur during early life verses adulthood.
The page was last updated on Tuesday, May 5, 2020 - 3:32pm