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COVID-19 Scientific Interest Group

The COVID-19 Scientific Interest Group was created in March 2020 in response to the COVID-19 pandemic. This interest group aims to promote collaboration and facilitate the exchange of information and resources among NIH intramural scientists and their HHS colleagues concerning research on COVID-19 and SARS-CoV-2.

Jump below to the following sections on this page:


Dashboard of NIH Intramural COVID-19 Projects (NIH-only)

The COVID-19 Scientific Interest Group, in collaboration with the Trans-NIH Preclinical Working Group, created an NIH Intramural Research Program (IRP) inventory and dashboard of COVID-19 projects. Currently, this dashboard can be accessed only by NIH leadership and the researchers who contributed information to it. NIH and other HHS-based researchers without direct access to this dashboard may find useful data on our spreadsheet IRP COVID-19 projects (last updated on May 18, 2020); note this requires access to the NIH network. If you have not submitted your COVID project for inclusion in the dashboard, you can fill out the form at IRP COVID-19 Projects. In summary:

 

 


Reagents (NIH-only)

The IRP COVID-19 Dashboard mentioned above also contains a list of reagents available to NIH researchers. NIH researchers without direct access to the dashboard may find relevant information in our spreadsheet of IRP COVID-19 reagents, also NIH-only (last updated on May 18, 2020). Distribution of any of the reagents is at the discretion of the principal investigator. If you have COVID-related reagents you are willing to make available to other IRP PIs, please fill out the form for the NIH COVID-19 Reagent Registry. In summary:

 

 


Samples and Safety Procedures

The NCI’s Division of Cancer Epidemiology and Genetics (DCEG) has established a repository for human-derived samples related to COVID-19 studies in the IRP within the existing DCEG biorepository, which already houses over 11 million tracked samples. You are invited to store such sample in this DCEG repository. They will be catalogued and tracked to assure proper storage and stewardship. The samples will be distributed according to the direction of the study’s PI. Please note that broad sharing through collaborations between IRP investigators and the extramural community (via appropriate MTAs) is expected in order to facilitate the rapid dissemination of science for the public good. 

Investigators with IRB-approved COVID projects that would like human biospecimen samples to be banked in the repository should contact Dr. Mandy Black in DCEG at blacka@mail.nih.gov. Unfortunately, live virus isolates and single samples cannot be stored at this time, but arrangements can be made to store samples that might be contaminated with virus. If extensive aliquoting is necessary, there may be a fee for service depending on the amount of work involved. Otherwise, DCEG has agreed to cover the costs of this important service. A catalogue of the contents of the repository will be made available very soon.

Safety: Please remember any work with potentially pathogen material including COVID-19 patient samples requires registration with the NIH IBC prior to any work being performed. These materials are registered as human blood and body fluids (COVID-19 Patient)". Materials and recombinant experiments, if applicable, are registered through the PI Dashboard (oms.ors.nih.gov). Contact your IC assigned safety representative for additional help or the NIH Biological Safety Officer, Rick Baumann, at baumannrg@mail.nih.gov.

 

 


Other Scientific Resources

The following list privides links to resources to assist in your research on SARS-CoV-2 and COVID-19.

  • Addgene: Addgene is a global, nonprofit repository that was created to help scientists share plasmids. Addgene has several COVID-19 and coronavirus plasmids and resources available.
  • BEI Resources Repository: BEI Resources was established by the National Institute of Allergy and Infectious Diseases (NIAID) to provide reagents, tools and information for studying Category A, B, and C priority pathogens, emerging infectious disease agents, non-pathogenic microbes and other microbiological materials of relevance to the research community. BEI Resources is prioritizing and fast-tracking all SARS-CoV-2 registrations. For SARS-CoV-2 requests, BEI anticipates a 24–72-hour registration turn-around time. Any researchers who need assistance with their registrations can contact BEI directly at 800-359-7370 or contact@beiresources.org
  • CREx: CREx is the collaborative research exchange for the NIH IRP. It enables PIs to find innovative services and suppliers and place orders for services or products they require. CREx has pre-established supplier legal and finance agreements that cover confidentiality, IP protection, and purchasing terms to allow for purchase on demand.
  • Jax Labs: The K18ACE2 tg mice expressing human ACE2 as a multicopy transgene are becoming available from Jax Labs. Humanized ACE2 mouse strains in which the endogenous ACE2 gene is mutated at a single or at multiple residues to enable virus entry into cells are being generated. Investigators at NIAID's Rocky Mountain Labs will be comparing the K18ACE2 and humanized ACE2 mice directly in terms of SARS-CoV-2 infection with the intent of making mice available to NIH researchers. Further information will be shared as available and when animals are closer to being ready for distribution by Jax.
  • NIAID’s COVID Resources for Researchers: Resources to support research and product development at each stage of the pipeline.
  • ViPR for structural and genomics data: The Influenza Research Database (IRD) and Virus Pathogen Resource (ViPR) are freely available, NIAID-funded resources that support the research of viral pathogens in the NIAID Category A-C Priority Pathogen lists and those causing re-emerging infectious diseases. IRD and ViPR integrate data from external sources (GenBank, UniProt, Immune Epitope Database, Protein Data Bank, etc.), direct submissions, and internal curation and analysis pipelines, and provide a suite of bioinformatics analysis and visualization tools to expedite virology research. 

 

 

 


Bibliographic Resources

The following list provides links to publications and guidance to assist in your research on SARS-CoV-2 and COVID-19.

  • COVID-19 Treatment Guidelines: These treatment guidelines have been developed to inform clinicians how to care for patients with COVID-19. Because clinical information about the optimal management of COVID-19 is evolving quickly, these guidelines are updated frequently as published data and other authoritative information becomes available.
  • COVID-19 Open Research Dataset Challenge (CORD-19): In response to the COVID-19 pandemic, the NIH, Allen Institute, and other leading research groups have prepared this resource of more than 128,000 scholarly articles, including over 59,000 with full text, about COVID-19, SARS-CoV-2, and related coronaviruses. 
  • iSearch COVID-19 portfolio: The iSearch COVID-19 portfolio is NIH’s comprehensive, expert-curated source for publications related to COVID-19. This COVID-19 Portfolio tool leverages the cutting-edge analytical capability of the iSearch platform, with its powerful search functionality and faceting, and includes articles from PubMed and pre-prints from medRxiv, SSRN, arXiv, bioRxiv, Research Square and ChemRxiv. The portfolio is updated daily with the latest available data.
  • NLM: The National Library of Medicine has reformatted its main landing page to highlight direct links to COVID-related studies, including clinical trials.

     

     

     


The COVID-19 SIG Lecture Series

“The Biomedical Research Response to COVID-19: A View from NIAID” (archived)
Hilary D. Marston, M.D., M.P.H. 
Medical Officer, Policy Advisor for Global Health, NIAID
Wednesday, April 15, 2020

“Rapid COVID-19 Vaccine Development: An Example of the Prototype Pathogen Approach for Pandemic Preparedness” (archived)
Barney Graham, M.D., Ph.D.
Deputy Director, Vaccine Research Center, NIAID
Wednesday, April 22, 2020

“COVID-19 Diagnostics: The Challenge of Rapid, High-Volume Detection of SARS-CoV-2” (archived)
Karen Frank, M.D., Ph.D.
Chief, Department of Laboratory Medicine, Clinical Center
Wednesday, April 29, 2020

“Animal Models for COVID-19: A Critical Component of the Response to the Pandemic” (archived)
Emmie de Wit, Ph.D.
Chief, Molecular Pathogenesis Unit, NIAID
Wednesday, May 6, 2020

“Clinical Trials in Public Health Emergencies: The Ebola and COVID Experiences" (archived)
Lori Dodd, Ph.D.
Mathematical Statistician, Biostatistics Research Branch, NIAID
Wednesday, May 13, 2020

“Sailing Close to the Breeze: Hospital Epidemiology in the COVID-19 Pandemic” (archived, NIH-only)
Tara Palmore, M.D.
Hospital Epidemiologist, Clinical Center
Wednesday, May 20, 2020, at 3:00 p.m.; to be available at videocast.nih.gov — HHS-only

"Structural Studies of Coronavirus Fusion Glycoproteins"
David Veesler, Ph.D.
Assistant Professor of Biochemistry, University of Washington
Wednesday, May 27, 2020, at 3:00 p.m.; to be available at videocast.nih.gov

Title TBA, a lecture on biological circuits, gene regulation
Aviv Regev, Ph.D.
Head of Roche's Genentech Research and Early Development (gRED)
Wednesday, June 3, 2020, at 3:00 p.m.; to be available at videocast.nih.gov

Title TBA, a lecture on nanoparticles and RNA vaccines
Dan Anderson, Ph.D.
Professor, Koch Institute for Integrative Cancer Research
Wednesday, June 10, 2020, at 3:00 p.m.; to be available at videocast.nih.gov

Title TBA, a lecture on SARS, MERS and the Australian COVID-19 experience
Kanta Subbaro, M.B.B.S.
Director of the WHO Collaborating Centre for Reference and Research on Influenza
Doherty Institute
Wednesday, June 17, 2020, at 4:00 p.m.; to be available at videocast.nih.gov

Title TBA, a lecture on SARS-CoV-2 protein interaction
Nevan Krogan, Ph.D.
Director, Quantitative Bioscience Institute (QBI)
University of California, San Francisco
Wednesday, June 24, 2020, at 3:00 p.m.; to be available at videocast.nih.gov

more to be scheduled…

 

 


E-mail List and MS Teams Site

 

 


COVID-19 SIG Leadership

The moderators for this group are: Mario Borgnia (NIEHS), Carson Chow (NIDDK), Michail Lionakis (NIAID), Vinay Pathak (NCI), Kaitlyn Sadtler (NIBIB), Pam Schwartzberg (NIAID), and Irini Sereti (NIAID). The NIH Office of Intramural Research representative is Charles Dearolf (dearolfc@mail.nih.gov).

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The page was last updated on Friday, May 22, 2020 - 5:41pm