Margaret Pittman Lecture
Part of the Wednesday Afternoon Lecture Series, the lecture is given by a researcher dedicated to advancing and improving the careers of women scientists. Since 1994 when this annual lecture began, every speaker has exemplified the intelligence, scientific excellence and drive that made Margaret Pittman a leader as the first female laboratory chief at NIH.
Cerebellar synaptic signaling as a metaphor for mentorship: how silence and speech get different deeds done
The cerebellum facilitates learned, coordinated movements and corrects errors. Signals to execute these functions are carried by the large neurons of the cerebellar nuclei, which form the major premotor projection from the cerebellum.
Dr. Linda Buck is a Howard Hughes Medical Institute Investigator, a Full Member of Fred Hutchinson Cancer Research Center, and an Affiliate Professor at the University of Washington. She received a B.S. from the University of Washington and a Ph.D. from the University of Texas Southwestern Medical Center. She was previously Full Professor of Neurobiology at Harvard Medical School. Dr.
Alternating electrostatic assembly is a tool that makes it possible to create ultrathin film coatings that contain highly controlled quantities of one or more therapeutic molecules within a singular construct. These release systems greatly exceed the usual ranges of traditional degradable polymers. The nature of the layering process enables the incorporation of different drugs within different regions of the thin-film architecture; the result is an ability to uniquely tailor both the independent-release profiles and order-of-release of each therapeutic to the targeted region of the body.
The advent of facile genome engineering using the bacterial RNA-guided CRISPR-Cas9 system in animals and plants is transforming biology. Dr. Doudna will present a brief history of CRISPR biology from its initial discovery through the elucidation of the CRISPR-Cas9 enzyme mechanism, providing the foundation for remarkable developments using this technology to modify, regulate or mark genomic loci in a wide variety of cells and organisms.
Autophagy is an essential catabolic cellular process that assures the maintenance of the cellular energetic balance as wells as an efficient removal of any intracellular damaged structure. In this talk, Dr. Cuervo will focus on selective forms of autophagy, and describe her lab’s recent advances on the identification of new molecular effectors and regulators for these pathways, the physiological role, and their changes in aging and age-related metabolic disorders and neurodegenerative diseases such as Parkinson, Alzheimer and Huntington disease.
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