Current Lecture Season
Noncoding (nc)RNAs play pivotal roles in the regulation of gene expression, but exhibit a diversity of functions whether encoded by cellular or viral genomes. One such ncRNA expressed in cells infected by the oncogenic gamma herpesvirus KSHV is the highly abundant polyadenylated nuclear (PAN) RNA, which is required for production and release of new virus particles.
The Reis e Sousa lab studies mechanisms involved in sensing infection, cancer, and tissue injury. Work from the lab has helped to define the cells and pathways involved in innate immune detection of RNA viruses, fungi and dead cells.
Dr. Nussenzweig’s laboratory studies the molecular aspects of the immune system’s innate and adaptive responses using a combination of biochemistry, molecular biology, and genetics. For work on adaptive immunity, he focuses on B lymphocytes and antibodies to HIV-1, while his studies of innate immunity focus on dendritic cells. His work is leading to new antibody-based therapies for infections by HIV and the novel SARS-CoV-2 coronavirus, among other viruses.
The Nelson laboratory’s research interests include elucidating the mechanisms by which cerebral blood flow is controlled to meet the diverse and ever-changing demands of active neurons and how these mechanisms are disrupted in small vessel disease (SVD)—a major cause of stroke and dementia. Dr.
Cell surface glycans constitute a rich biomolecular dataset that drives both normal and pathological processes. Their “readers” are glycan-binding receptors that can engage in cell-cell interactions and cell signaling. Our research focuses on mechanistic studies of glycan/receptor biology and applications of this knowledge to new therapeutic strategies. Our recent efforts center on pathogenic glycans in the tumor microenvironment and new therapeutic modalities based on the concept of targeted degradation.
Dr. Cooper’s research program examines the effectiveness of multilevel strategies for advancing health equity in the United States and Sub Saharan Africa. She has conducted observational studies to describe attitudinal barriers to equitable health status and health care among patients from diverse racial and ethnic groups, and to elucidate mechanisms, such as the quality of social relationships, for racial and socioeconomic disparities in health status and healthcare.
Dr. Ellen Sidransky is the Branch Chief of the Medical Genetics Branch and is a pediatrician and geneticist in the National Human Genome Research Institute at National Institutes of Health (NIH). Her research interests include both clinical and basic aspects of Gaucher disease and Parkinson disease, studies of genotype/phenotype correlation and genetic modifiers, insights from mouse models, and novel treatment strategies. She played a lead role in establishing the association between glucocerebrosidase and parkinsonism.
We have established a systems neuroscience (conceptual, experimental, data analysis and modeling) paradigm for studying the mechanisms of general anesthesia-induced loss of consciousness.
The Orth lab is interested in elucidation the activity of virulence factors from pathogenic bacteria so that we can gain novel molecular insight into eukaryotic signaling systems.
Many virulence factors are secreted by bacteria using a type III secretion system (T3SS) resembling a needle-like structure that efficiently translocates effector proteins from bacteria into the cytosol of a host cell. Effectors have evolved in a manner similar to many of the viral oncogenes; a eukaryotic activity is usurped and modified by the pathogen for its own advantage.
The Kirkegaard laboratory deciphers the genetics of RNA viruses and their mammalian hosts, with the goal of suppressing drug resistance and excessive inflammation during viral infections.
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