Current Lecture Season
Dr. Sadik is a Distinguished Professor and Chair in the Department of Chemistry and Environmental Sciences at the New Jersey Institutes of Technology (NJIT). Until recently, Sadik was a Professor of Chemistry and Director of the Center for Research in Advanced Sensing Technologies & Environmental Sustainability at SUNY-Binghamton. She has held appointments at Harvard University, Cornell University, and the Naval Research Laboratory.
Fueling the Next Genomic Revolution: Maximizing the Impact of Bacterial, Human, and Human Metagenome Genomic Knowledge and Technology (Panel Discussion)
This lecture and panel discussion will be led by Dr. Francis Collins and will feature Dr. Eric Lander, President and Founding Director of the Broad Institute of MIT and Harvard, Dr. Claire Fraser, Director of the Institute for Genome Sciences at the University of Maryland, and Dr. Charles Rotimi, Chief of the Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch at NHGRI. Dr.
The Orth lab is interested in elucidation the activity of virulence factors from pathogenic bacteria so that we can gain novel molecular insight into eukaryotic signaling systems.
Many virulence factors are secreted by bacteria using a type III secretion system (T3SS) resembling a needle-like structure that efficiently translocates effector proteins from bacteria into the cytosol of a host cell. Effectors have evolved in a manner similar to many of the viral oncogenes; a eukaryotic activity is usurped and modified by the pathogen for its own advantage.
Aviv Regev, a computational and systems biologist, is a professor of biology at MIT, a Howard Hughes Medical Institute Investigator, the Chair of the Faculty and the director of the Klarman Cell Observatory and Cell Circuits Program at the Broad Institute of MIT and Harvard, and co-chair of the organizing committee for the international Human Cell Atlas project. She studies the molecular circuitry that governs the function of mammalian cells in health and disease and has pioneered many leading experimental and computational methods for the reconstruction of circuits, including in single-cel
Dr. Yaffe's research focuses on the epidemiology of dementia and cognitive aging. As the principal investigator of multiple grants from the NIH, Department of Defense, and several foundations, she is a leading expert in the modifiable risk factors of dementia, and she has published over 500 peer-reviewed articles (H-index=130; recognized by Clarivate Analytics as one of the most highly cited researchers in her field). Dr.
Dr. Eve Higginbotham is the inaugural Vice Dean for Inclusion and Diversity of the Perelman School of Medicine at the University of Pennsylvania, a position she assumed on August 1, 2013. She is also a Senior Fellow at the Leonard Davis Institute for Health Economics and Professor of Ophthalmology at the University of Pennsylvania. She is the immediate past president of the AΩA Medical Honor Society and currently serves on the National Academy of Medicine Council and the National Research Council Board. Dr.
Rachel Green began her scientific career majoring in chemistry as an undergraduate at the University of Michigan. Her doctoral work was performed at Harvard in the laboratory of Jack Szostak where she studied RNA enzymes and developed methodologies for evolving RNAs in vitro. She came to the JHU School of Medicine in 1998 following post-doctoral work in Harry Noller’s lab at UC Santa Cruz where she began her work on ribosomes. Her laboratory is interested in deciphering the molecular mechanisms that are at the heart of protein synthesis and its regulation across biology.
The Kirkegaard laboratory deciphers the genetics of RNA viruses and their mammalian hosts, with the goal of suppressing drug resistance and excessive inflammation during viral infections.
Increasing prevalence and severity of multi-drug-resistant bacterial infections require novel management strategies. One possible strategy is a renewed approach to ‘phage therapy,’ where these administered viruses not only kill the target bacteria, but also predictably select for phage resistance that reduces virulence and/or increases antibiotic sensitivity (evolutionary trade-offs).
Our research interests revolve around obtaining a better understanding of the interaction of retroviruses with their host cells and organisms. We use simple retroviruses (avian and murine viruses) as well as HIV to elucidate the nature of the retrovirus-receptor interaction; control of viral gene expression; mechanism of retroviral genetic variation; and evolution of the host-virus relationship, as revealed by the fossil record provided by endogenous proviruses found in the normal DNA of all vertebrates and many other species.
The page was last updated on Wednesday, June 11, 2014 - 4:07pm