The Microscope as a Tool for Disease Discovery
G. Burroughs Mider Lecture | to
Elaine S. Jaffe, M.D.
NIH Distinguished Investigator
Laboratory of Pathology, NCI/CCR
Dr. Jaffe completed her medical education at Cornell University and the University of Pennsylvania, receiving an M.D. from the latter in 1969. After an internship at Georgetown University, she joined the NCI as a resident in anatomic pathology, and has been a senior investigator since 1974, focusing on the classification and definition of lymphoid neoplasms. She has served on the editorial boards of The American Journal of Pathology, The American Journal of Surgical Pathology, Blood, Cancer Research, and Modern Pathology, among others. She has been president of both the Society for Hematopathology as well as the United States and Canadian Academy of Pathology, and was elected to the advisory board of the American Society of Hematology. In 1993, she was elected a fellow of the American Association for the Advancement of Science, and in 2005 was Chair of the Medical Sciences Section of AAAS. She was among the 10 most highly cited researchers in clinical medicine for the field of oncology between 1981 and 1998. Among her awards are the Fred W. Stewart Award from Memorial-Sloan Kettering Cancer Center, the Mostofi Award from the United States and Canadian Academy of Pathology, and the Distinguished Clinical Teacher Award from the NIH Fellows Committee. In 2007 she was the second Anita Roberts Lecturer, recognizing women in science at the NIH. She was awarded the Honoris Causa from the University of Barcelona in 2008, and received the Chugai Award for Excellence in Mentoring and Scholarship from the American Society of Investigative Pathology. In 2008 she was elected to the Institute of Medicine of the National Academies. Dr. Jaffe was awarded the Henry M. Stratton Medal from the American Society of Hematology in 2013.
Summary
The lecture will briefly review the historical background of the modern classification of lymphomas. The contemporary classification of lymphomas begins with traditional pathological observations, but defines diseases based on an integration of histological features, the nature of the tumor cells as they relate to the normal immune system, genomic findings, and finally clinical presentation and course. The lecture will illustrate how observations made in the course of daily practice lead to the discovery of new diseases, and how these discoveries impact clinical management.
Learning Objectives
- To gain an understanding of the biological principles that underpin the modern classification of lymphoma.
- To demonstrate lymphomas as neoplastic caricatures of the immune system.
- To illustrate how the discovery of new diseases can emerge from observations made in the daily diagnostic setting
https://videocast.nih.gov/watch=55025
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