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        • Clarification on Searches for Scientific Director and Clinical Director
        • Departing Staff Request to Remove Copies of NIH Records
        • Extension Exceptions for Non-FTE Trainees for COVID-19
        • Fair Review Principles for Nominations of Staff Scientists for Associate Scientist and Senior Associate Scientist Titles
        • Guide for Avoiding Undue Foreign Interference with IRP Research
        • Guidelines for Parental/Family Excused Absence for IRTAs, CRTAs, and Visiting Fellows
        • Mandated Training for Scientific Staff Working in NIH Facilities
        • Policy for a Letter of Agreement for Staff Scientists
        • Policy for Reassignment or Early Termination of Awards to Postbaccalaureate Fellows
        • Policy for Reassignment or Early Termination of Awards to Postdoctoral Fellows
        • Policy for Reassignment or Early Termination of Awards to Predoctoral Fellows
        • Policy for Use of Contract Workers to Support Scientific Functions in the IRP
        • Policy on Use of English for Official Scientific Communication in NIH Laboratories and Branches
        • Postdoctoral Fellows (IRTA/CRTA/VF) Temporary Exceptional Extensions Policy
        • Roles of Lab and Branch Chiefs (or Equivalent)
        • Telework Policies for IRTA/CRTA and Visiting Fellows
        • Working with Displaced Title 42 Staff Scientists/Clinicians
      • Quality-of-Life Features
      • Sabbaticals
        • NIAAA Sabbatical Program
        • NEI Sabbatical Program
        • NICHD Sabbatical Program
        • PHS Foreign Work / Study Program Policy
      • Opportunities for Short Assignments / Details at the NIH
    • Tenure in the NIH Intramural Research Program
      • Tenure-Track Overview
      • Search & Selection
        • Search Process for Senior Investigators, Tenure-Track Investigators, Senior Clinicians and Senior Scientists
      • Additional Tenure-Track Policies
      • Resources
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      • Eligibility of Intramural Investigators for NIH Common Fund Awards
      • K99/R00 Grant Award Information
        • Application Approval Process and Additional Information
        • K99/R00 Environment and Institutional Commitment Statement
        • Update from Scientific Directors
      • NIAID Support of Intramural Biodefense Research from ICs Other Than NIAID
    • Ethical Conduct
      • Research Misconduct
        • Anonymous Reporting of Research Misconduct Concerns
        • Taraswi Banerjee, Ph.D.
        • Alfredo R Sancho, Ph.D., M.P.H.
      • Guidelines on Conduct of Research
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          • Intramural / Extramural Collaborations
            • NIH Staff Involvement on Extramural Awards - Cooperative Agreements
              • Opportunities for Collaborative Research at the Clinical Center (U01)
              • NIH Bench-to-Bedside Program
            • Activities with Outside Organizations
          • NIH Human Biospecimen Program
            • Frequently Asked Questions
            • List of Biospecimen Liaisons
          • Investigation of Allegations of Research Misconduct
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        • Authorship Resources
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        • Dual-Use Research
        • Policy on the Ordering or Provision of Synthetic Nucleic Acids in the IRP
        • Human Stem Cell Use
          • Human Embryonic Stem Cell (hESCs) Use
          • Induced Pluripotent Stem Cells (iPSCs) Use
          • Human Embryo Research and Cloning Prohibitions
        • Policies & Procedures for Human Fetal Tissue Research
      • Responsible Conduct of Research Training
        • Instruction in Responsible Conduct of Research - Postdoc IRTA, CRTA, VF, Research Associates
          • Reproducibility Training
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    • The NIH Intramural Database collects and disseminates information about research being performed in the Intramural Programs
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Intramural / Extramural Collaborations

TO: All Intramural and Extramural Staff
FROM: Nina F. Schor M.D., Ph.D., Deputy Director for Intramural Research, NIH, and Michael S. Lauer, M.D., Deputy Director for Extramural Research, NIH
SUBJECT: Funding of Intramural/Extramural Collaborations

Collaborations between intramural and extramural scientists are encouraged, but the nature of these collaborations must be clear to assure proper management of NIH resources, and appropriate conflict of interest statutes are carefully observed (see Sourcebook: Activities with Outside Organizations).

For Scientists Paid with Intramural Funds

Grant Writing

The main purpose of this memorandum is to remind everyone in the intramural program that scientists paid with intramural funds may not receive salary support or any other funds from NIH extramural grants, either as Principal Investigators or Program Directors (PI/PD), other key staff, or consultants. During the time in which scientists are paid with intramural funds, they may not serve as principal investigators on NIH grants, including grants/cooperative agreements for which there are multiple PIs (MPIs) funded under a project, nor are they allowed to receive monetary support from the grant. They may serve as an unfunded coInvestigator (co-I) on a grant/cooperative agreement submitted by an extramural applicant under the leadership of an extramural PI. Intramural scientists may prepare grant applications on their own time for submission to a nonFederal organization for research that will commence after they leave Federal employment (see NIH Manual Chapter 54204/6003-1).

Collaboration

Collaboration, such as the use of the cooperative agreement award mechanism (U01 activity code), involves a significant contribution to the conceptualization, design, execution, or interpretation of the research study. Simply providing unique biological materials, such as cell lines, antibodies, and probes, does not constitute a collaboration(see NIH Guidelines for the Conduct of Research). NIH scientists may serve as unpaid collaborators, co-Is, or unpaid consultants on extramural grants. They are not allowed to serve as key personnel on the extramural award. In these cases, a formal letter from the intramural scientist must be included as part of the grant application with a copy of this letter sent to the Scientific Director. The letter should be limited to a description of the intramural scientist’s collaborative work under the grant. The grant applicant is responsible for writing the section of the grant that describes the proposed collaboration within the grant, which the NIH investigator should see and approve.

Cooperative Agreements

In some cases, the work of the intramural scientist is such a substantial part of the proposal that the award may need to be managed as a cooperative agreement. Circumstances defining when a grant should be managed as a cooperative agreement are defined on the attached document entitled “Cooperative Agreements”. If an intramural scientist believes that his/her contribution requires a cooperative agreement, the Scientific Director should be alerted when the letter of collaboration is submitted, and, if appropriate, the Scientific Director should notify the grants management office of their Institute or Center about the nature of the collaboration.

Guest Researchers

Guest Researchers at the NIH are not paid with NIH intramural funds and are working in the intramural program on projects of their own choosing; however, they may be involved in NIH-funded extramural projects. Any use of NIH intramural facilities to conduct research supported by NIH, or other federal extramural grants, must be approved in advance by the Scientific Director who will notify the grants management office of the Institute/Center or the federal granting agency providing the funding, if such use requires a cooperative agreement.

Special Volunteers

Special Volunteers, by definition, perform services for the NIH on their own time that are not associated with their outside employment (see NIH Manual Chapter 2300-308-1). Scientific Directors must be sure there is no conflict of interest such as would occur if the support came from organizations that do business with the NIH or are currently receiving grants from the NIH. If questions arise, the Scientific Director should consult with the Institute Deputy Ethics Counselor, usually the Institute Director, and the NIH Legal Advisor prior to accepting volunteer services from individuals receiving compensation from outside organizations.

Researchers are advised to consider the guidance on inappropriate foreign collaborations of any kind prior to engaging in any of the above activities with a foreign entity.

Although these rules are complex, continued public support of our research depends on appropriate stewardship of federal funds.

/s/

Nina F. Schor, M.D., Ph.D., DDIR
Michael S. Lauer, M.D., DDER

First Established: Wednesday, December 1, 1999

Modifications:

  • Tuesday, October 20, 2009
  • Sunday, February 1, 2015
  • Tuesday, August 18, 2020
  • Friday, May 31, 2024

This page was last updated on Thursday, July 11, 2024

Main navigation

  • Board of Scientific and Clinical Directors
    • Board of Scientific and Clinical Directors Membership
    • NIH IRP Scientific Directors
    • NIH IRP Clinical Directors
    • Board of Scientific and Clinical Directors Subcommittees
  • Committees Advisory to the DDIR
    • Assembly of Scientists (AOS)
    • Committee on Scientific Conduct and Ethics (CSCE)
    • Central Tenure Committee (CTC)
    • Chairs of the Boards of Scientific Counselors
    • Tenure-Track Investigators Committee
    • Women Scientist Advisors (WSA) Committee
    • Animal Research Advisory Committee (ARAC)
    • Dual Use Research of Concern (DURC) Committee
    • Facilities Working Group
    • NIH Space Recommendation Board
    • PHS Technology Transfer Policy Board
  • Processes for Reviewing NIH Intramural Science
    • Boards of Scientific Counselors (BSC)
      • Process for Appeal to a BSC Review
    • Role and Review of Scientific Directors and Clinical Directors
    • Blue Ribbon Panel Reviews of IC Intramural Research Programs
  • Intramural Program Oversight
    • Electronic Lab Notebooks
      • Intramural Electronic Lab Notebook Policy
      • Frequently Asked Questions About the Use of ELNs at NIH
    • Human Subjects Research
    • Intramural Data Sharing
      • 2023 NIH Data Management and Sharing Policy
      • Genomic Data Sharing
      • Human Data Sharing
      • Guide to FDAAA Reporting Research Results
        • Frequently Asked Questions: NIH Clinical Trial Definition
        • Assistance Available to Help with Results Reporting to ClinicalTrials.gov
          • Points of Contact for FDAAA Compliance at ICs
    • IRP Research Security
    • Laboratory Safety
    • Management Controls Survey
  • Intramural Administrative Management Council
    • List of Council Members
    • List of Trans-NIH Committees
  • Personnel
    • IPDs and Appointment Mechanisms
      • Official List of Approved Intramural Professional Designations (IPDs)
      • Senior Investigator
      • Investigator
      • Senior Clinician
      • Senior Scientist
      • Assistant Clinical Investigator
      • Staff Clinician
      • Staff Scientist
        • Explanation of Staff Scientist Position and Titles to Academic Colleagues
      • Senior Research Assistant / Research Assistant
      • Adjunct Investigator
      • Scientist Emeritus
      • Intramural Research Training Award (IRTA) Fellow
      • Visiting Fellow
      • ORISE Senior Fellow
      • Senior Clinical Fellow
      • Clinical Fellow
      • Senior Research Fellow
      • Research Fellow
        • Independent Research Scholar Program
      • Student Opportunities
      • Contractors
      • Guest Researchers / Special Volunteers
      • Research Collaborators
    • Faculty Development
      • 2024 OITE/OIR Professional Development Curriculum for NIH Faculty
      • Senior Advisors for Faculty Development
    • Policies and Recruitment Processes
      • 5-Year / 8-Year Duration Rule
      • Addendum to On-Site Research Collaborators (RC) Policies: On-Site RC Conducting Human Subjects Research at NIH
      • Clarification on Searches for Scientific Director and Clinical Director
      • Departing Staff Request to Remove Copies of NIH Records
      • Extension Exceptions for Non-FTE Trainees for COVID-19
      • Fair Review Principles for Nominations of Staff Scientists for Associate Scientist and Senior Associate Scientist Titles
      • Guide for Avoiding Undue Foreign Interference with IRP Research
      • Guidelines for Parental/Family Excused Absence for IRTAs, CRTAs, and Visiting Fellows
      • Mandated Training for Scientific Staff Working in NIH Facilities
      • Policy for a Letter of Agreement for Staff Scientists
      • Policy for Reassignment or Early Termination of Awards to Postbaccalaureate Fellows
      • Policy for Reassignment or Early Termination of Awards to Postdoctoral Fellows
      • Policy for Reassignment or Early Termination of Awards to Predoctoral Fellows
      • Policy for Use of Contract Workers to Support Scientific Functions in the IRP
      • Policy on Use of English for Official Scientific Communication in NIH Laboratories and Branches
      • Postdoctoral Fellows (IRTA/CRTA/VF) Temporary Exceptional Extensions Policy
      • Roles of Lab and Branch Chiefs (or Equivalent)
      • Telework Policies for IRTA/CRTA and Visiting Fellows
      • Working with Displaced Title 42 Staff Scientists/Clinicians
    • Quality-of-Life Features
    • Sabbaticals
      • NIAAA Sabbatical Program
      • NEI Sabbatical Program
      • NICHD Sabbatical Program
      • PHS Foreign Work / Study Program Policy
    • Opportunities for Short Assignments / Details at the NIH
  • Tenure in the NIH Intramural Research Program
    • Tenure-Track Overview
    • Search & Selection
      • Search Process for Senior Investigators, Tenure-Track Investigators, Senior Clinicians and Senior Scientists
    • Additional Tenure-Track Policies
    • Resources
    • Policy on IC Tenure Review Committees
    • Tenure Overview
    • Search & Selection
    • Criteria for Tenure at the NIH
    • De-Tenuring Process
  • Awards, Fellowships, & Grant Opportunities
    • The Director’s Challenge Innovation Award Program
      • 2020 Director’s Challenge Awards
      • 2022 Director’s Challenge Awards
      • 2024 Director’s Challenge Awards
    • Early Career (Bridge) Awards Open to IRP Scientists
    • Eligibility of Intramural Investigators for NIH Common Fund Awards
    • K99/R00 Grant Award Information
      • Application Approval Process and Additional Information
      • K99/R00 Environment and Institutional Commitment Statement
      • Update from Scientific Directors
    • NIAID Support of Intramural Biodefense Research from ICs Other Than NIAID
  • Ethical Conduct
    • Research Misconduct
      • Anonymous Reporting of Research Misconduct Concerns
      • Taraswi Banerjee, Ph.D.
      • Alfredo R Sancho, Ph.D., M.P.H.
    • Guidelines on Conduct of Research
    • Research Ethics
      • NIH Policies
        • Intramural / Extramural Collaborations
          • NIH Staff Involvement on Extramural Awards - Cooperative Agreements
            • Opportunities for Collaborative Research at the Clinical Center (U01)
            • NIH Bench-to-Bedside Program
          • Activities with Outside Organizations
        • NIH Human Biospecimen Program
          • Frequently Asked Questions
          • List of Biospecimen Liaisons
        • Investigation of Allegations of Research Misconduct
      • NIH Guidelines
    • Authorship Guidelines and Resources
      • Authorship Resources
      • NIH IRP Authorship Conflict Resolution Process
    • Special Research Considerations
      • Dual-Use Research
      • Policy on the Ordering or Provision of Synthetic Nucleic Acids in the IRP
      • Human Stem Cell Use
        • Human Embryonic Stem Cell (hESCs) Use
        • Induced Pluripotent Stem Cells (iPSCs) Use
        • Human Embryo Research and Cloning Prohibitions
      • Policies & Procedures for Human Fetal Tissue Research
    • Responsible Conduct of Research Training
      • Instruction in Responsible Conduct of Research - Postdoc IRTA, CRTA, VF, Research Associates
        • Reproducibility Training
        • Introduction to “My Laboratory”
      • Instruction in Responsible Conduct of Research - Postbacs and GPP Students
      • Resources for Training Directors
      • Annual Review of Ethics (Case Studies)
        • Research Cases for Use by the NIH Community
          • 2021 Ethics Case Facilitator Training
    • Government Ethics
      • Guidelines for Non-FTEs (Trainees) for NIH-Related Activities, Outside Activities, and Awards
    • Bioethics
  • Mentoring & Training
    • Guide to Training and Mentoring
    • Guidelines for Mentors at NIH
    • Guidelines for Trainees at NIH
    • Guidelines for Annual Progress Review of Trainees
    • Scientific Director Policy Updates for Mentors and Trainees
    • Goals for Enhanced Mentoring in the IRP
    • FelCom Mentoring Committee
    • Mentoring Cases for Discussions
  • Submitting Research Publications
    • PubMed Central (PMC) Deposition Requirements
    • Intramural Directions for Submitting to PubMed Central via NIHMS
    • NIH Publishing Agreement Forms
      • Procedures for Non-Peer-Reviewed Publications
    • Publication and Abstract Clearance
  • Intramural Research Communications & Resources
    • Annual Reports and Bibliographies
  • Email
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Main navigation

  • About OIR
    • OIR Leadership & Staff
    • DDIR Innovation Awards
    • Long-Term IRP Planning
    • OIR Offices
  • Sourcebook
    • Board of Scientific and Clinical Directors
    • Committees Advisory to the DDIR
    • Processes for Reviewing NIH Intramural Science
    • Intramural Program Oversight
    • Intramural Administrative Management Council
    • Personnel
    • Tenure in the NIH Intramural Research Program
    • Awards, Fellowships, & Grant Opportunities
    • Ethical Conduct
    • Mentoring & Training
    • Submitting Research Publications
    • Intramural Research Communications & Resources
  • Lectures & Events
    • WALS
    • NIH Research Festival
  • SIGs
    • SIGs by Name
    • SIGs by Scientific Focus Area
  • IRP Website
    • A premier environment where creative scientists conduct fundamental research for the betterment of human health – we are the IRP
    • Visit Website
  • The NIH Catalyst
    • A publication for and about the NIH intramural research community
    • Visit Website
  • NIDB
    • The NIH Intramural Database collects and disseminates information about research being performed in the Intramural Programs
    • Visit Website
  • Department of Health and Human Services
  • National Institutes of Health
  • USA.gov

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