Reproducibility Training

One hour of Supervisory Training will be awarded for completion of one hour of interaction with Lab Staff/trainees on Reproducibility and Study design. There are four video vignettes with associated discussion questions. The PI may choose which to use. These examples should be viewed as a starting point for discussions about best practices for designing experiments and how to relate them to the research environment.

REPRODUCIBILITY TRAINING MODULES

Introduction

NIH Experimental Design and Reproducibility Modules (for discussion, no video)

• Discussion Document

Lack of Transparency

• Discussion Document

Blinding and Randomization

• Discussion Document

Biological and Technical Replicates

• Discussion Document

Additional Materials that Can be Used for Discussion

Reproducibility: Experimental Design
One of the components which contribute most to Reproducibility is good experimental design. David Glass, a noted authority and author of a textbook used in a short course on Experimental Design for Biologists (Cold Spring Harbor Laboratory Press, 2007) spoke at NIGMS in August of 2014. His presentation was recorded and is available for viewing at the following location:

• https://videocast.nih.gov/launch.asp?18544

Resources

• Credibility and Reproducibility, Cell Editorial
• Dealing with Irreproducibility, The Scientist
• Survey of Quality of Experiment Design, Statistical Analysis and Reporting of research Using Animals
• A call for transparent reporting to optimize the predictive value of preclinical research
• Principals and Guidelines for Reporting Preclinical Research
• Rigor or Mortis: Best Practices for Preclinical Research in Neuroscience
• Science mapping analysis characterizes 235 biases in biomedical research
• Special Report on Reproducibility, Burrows-Welcome Fund: Biomedical Research: Are all the results correct?