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NIH Director’s Wednesday Afternoon Lecture Series

Upcoming Lectures

Human Oncogenic Viruses: Nature and Discovery

May 12, 2021 - 3:00pm to 4:00pm
Yuan Chang, M.D., University of Pittsburgh

Our laboratory performs basic and applied research on viral oncogenesis with efforts focused in the following three areas. 

Merkel cell carcinoma and Merkel cell polyomavirus. We recently discovered a new human polyomavirus, that we call Merkel cell polyomavirus (MCV). This virus is etiologically associated with a rare, but one of the most clinically aggressive skin cancers in humans. We are currently involved in the primary characteristics of this virus including transcript mapping, transforming properties, origin replication, transmission, and seroepidemiologic studies.

The AI Path to Deeper and More Accurate Medicine

May 19, 2021 - 3:00pm to 4:00pm
Eric Topol, M.D., Scripps Research Institute

My research is on individualized medicine, using the genome and digital technologies to understand each person at the biologic, physiologic granular level to determine appropriate therapies and prevention. An example is the use of pharmacogenomics and our research on clopidogrel (Plavix). By determining the reasons for why such a large proportion of people do not respond to this medication, we can use alternative treatment strategies to prevent blood clots.

Droplets, droplets everywhere…cell organization by liquid-liquid phase separation

May 26, 2021 - 3:00pm to 4:00pm
Michael K. Rosen, Ph.D., UT Southwestern Medical Center

The Rosen lab seeks to understand the formation, regulation and functions of enigmatic, cellular compartments termed biomolecular condensates. These evolutionarily conserved structures concentrate diverse but specific groups of molecules without a surrounding membrane. Condensates appear to form through the physical process of liquid-liquid phase separation. Using a range of techniques, including biochemical reconstitution and in vitro and cellular microsopies, we investigate phase separation in both engineered and natural condensates. The former, in their simplified nature, enable

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