NIH Director’s Wednesday Afternoon Lecture Series

Biomedical Research in Rural America: Much Accomplished, Much To Do

Wednesday, November 30, 2022, 3:00 to 4:00pm
DeWitt Stetten Jr. Lecture
Sally L. Hodder, M.D., West Virginia University

This will be a remote-only lecture at https://videocast.nih.gov/watch=46035 with a start time of 3:00 p.m. ET (and not 2:00 p.m. like all other WALS talks.) No registration is needed.

Mutant p53 Activities in Mouse Tumor Models

Wednesday, December 7, 2022, 3:00 to 4:00pm
Margaret Pittman Lecture
Gigi Lozano, Ph.D., University of Texas MD Anderson Cancer Center

NEW TIME AND PLACE: 3 P.M. IN WILSON HALL, BUILDING 1 — Mutation of the p53 gene is a critical event in the elaboration of many tumors of diverse origin. The p53 protein is activated in response to DNA damage, serving as a checkpoint in the elimination or repair of cells with damaged DNA. Alterations in components of the p53 pathway, such as amplification of the Mdm2 gene, which encodes a p53 inhibitor, also contribute to tumorigenesis.

The Coming of Age of De Novo Protein Design

Wednesday, December 14, 2022, 2:00 to 3:00pm
David Baker, Ph.D., University of Washington, Seattle

David Baker is the director of the Institute for Protein Design, a Howard Hughes Medical Institute Investigator, the Henrietta and Aubrey Davis Endowed Professor in Biochemistry, and an adjunct professor of genome sciences, bioengineering, chemical engineering, computer science, and physics at the University of Washington. His research group is focused on the design of macromolecular structures and functions.

He received his Ph.D. in biochemistry with Randy Schekman at the University of California, Berkeley, and did postdoctoral work in biophysics with David Agard at UCSF.