NIH Director’s Wednesday Afternoon Lecture Series
This lecture will focus on the use of integrated data large-scale sets to understand and predict disease. Dr. Singleton will discuss attempts to make headway in identifying at-risk patients earlier, when interventions may be most effective.
Neuropathic pain arises, in part, from a nerve injury-induced loss of spinal cord GABAergic inhibitory controls. Here we asked whether the neurological consequences of peripheral nerve damage can be overcome by transplanting embryonic cortical GABAergic precursor cells into the spinal cord. Using electrophysiological, neuroanatomical and behavioral approaches, we found that the cells integrate into host spinal cord circuits and can ameliorate the persistent pain and itch associated with nerve damage.
The King laboratory uses molecular and comparative genomic approaches to reconstruct the origin and evolution of animals. To this end, we have developed choanoflagellates, the closest living relatives of animals, into genome-enabled and experimentally-tractable organisms for investigating the unicellular ancestry of animals. Our research has revealed the unicellular ancestry of many key aspects of animal genomes and cell biology.
The page was last updated on Monday, March 23, 2015 - 3:00pm