NIH Director’s Wednesday Afternoon Lecture Series
MicroRNAs (miRNAs) are short RNAs that pair to sites within messenger RNAs (mRNAs) to down-regulate the expression of protein-coding genes. These miRNAs play critical roles in mammalian biology and disease. Indeed, because miRNAs specify the repression of most human genes, it is hard to find a disease, developmental process, or physiological state that is not influenced in some way by miRNAs. For his lecture, Dr. Bartel will present an overview of miRNAs and their regulatory roles.
The information for this lecture has not yet been made available. Please check back soon for an updated overview.
It has been a long standing goal to develop molecular biomarkers of biological age. Recent studies demonstrate that powerful epigenetic biomarkers of aging can be defined based on DNA methylation levels. For example, the epigenetic clock (PMID: 24138928) is a multivariate age estimation method that applies to sorted cell types (CD4T cells or neurons), complex tissues, and organs and even prenatal brain samples.
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