NIH Director’s Wednesday Afternoon Lecture Series

RESCHEDULED FOR JAN. 27, 2021 – Black Spot, Black Death, Black Pearl: the Tales of Bacterial Effectors

Dr. Orth's lecture has been rescheduled to January 27, 2021. 

The Orth lab is interested in elucidation the activity of virulence factors from pathogenic bacteria so that we can gain novel molecular insight into eukaryotic signaling systems.

POSTPONED – CFTR, the Odd ABC Transporter Responsible for Cystic Fibrosis

We study ATP-binding cassette (ABC) transporters, a diverse group of membrane proteins integral to almost every biological process. In prokaryotes, these proteins are critical for survival. In humans, ABC transporters make up one of the largest gene families, and more than a dozen genetic diseases have been traced to ABC transporter defects. ABC transporters are also central to multidrug resistance in many pathogenic bacteria and in tumor cells.

POSTPONED – Casting the Net Wide: the Role of Neutrophils in Chronic Diseases

Dr. Kaplan's research has focused on identifying mechanisms of immune dysregulation, organ damage and premature vascular disease in systemic autoimmunity. More specifically, she investigates how innate immunity (in particular, type I interferons and myeloid cells) promote end-organ damage in systemic lupus erythematosus, rheumatoid arthritis and other systemic autoimmune diseases.