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NIH Director’s Wednesday Afternoon Lecture Series

Upcoming Lectures

Tools for analyzing and repairing complex biological systems

September 2, 2015 - 3:00pm to 4:00pm
Edward Boyden, Ph.D. , Massachusetts Institute of Technology

The goal of the Boyden laboratory is to achieve ground truth understandings of complex biological systems, including entire cells and entire brains, and to use such insights to improve the human condition through novel inventions and therapeutics. To make this possible, Dr. Boyden and his colleagues are currently creating technologies that enable comprehensive observation and control of biological systems, aiming for molecular precision, millisecond resolution, and whole organ scale.

Aquaporin water channels—from transfusion medicine to malaria

September 9, 2015 - 3:00pm to 4:00pm
Peter Agre, M.D. , Johns Hopkins Malaria Research Institute

Biochemical analysis of the Rhesus blood group antigen led to the serendipitous discovery of AQP1, the first molecular water channel. Found throughout nature, aquaporin water channels confer high water permeability to cell membranes. AQP1 has been characterized biophysically, and the atomic structure of AQP1 is known. Identification of the Colton blood group antigen on the extracellular domain of AQP1 allowed identification of rare individuals who are AQP1-null and manifest a subclinical form of nephrogenic diabetes insipidus. Thirteen homologous proteins exist in humans.

The AML genome(s): Mutations in four dimensions

September 30, 2015 - 3:00pm to 4:00pm
Timothy J. Ley, M.D. , Washington University School of Medicine

For many years, Dr. Ley's laboratory has used mouse models of acute myeloid leukemia (AML) to establish key principles of AML pathogenesis. The lab established that the initiating event for Acute Promyelocytic Leukemia is the PML-RARA fusion gene created by the t(15;17) that is found in nearly all patients with this disease. The roles of cooperating mutations and the cellular milieu for APL pathogenesis have also been established.

The page was last updated on Monday, March 23, 2015 - 3:00pm