NIH Director’s Wednesday Afternoon Lecture Series
Over the years, Dr. Germain and his colleagues have made key contributions to our understanding of Major Histocompatibility Complex (MHC) class II molecule structure–function relationships, the cell biology of antigen processing, and the molecular basis of T cell recognition. More recently, his laboratory has been focused on the relationship between immune tissue organization and dynamic control of adaptive immunity at both the initiation and effector stages.
Research in the Brinton laboratory is focused on discovery of mechanisms by which the aging brain develops late onset Alzheimer’s and therapeutics that target these mechanisms to prevent, delay and treat the disease. Our research spans basic mechanistic discovery to FDA IND enabling translational analyses to Phase 1 and 2 clinical trials.Our NIA sponsored discovery research has investigated the neuro-systems-biology of aging in the sex with greatest risk of developing late onset Alzheimer’s.
The research in the Bartolomei laboratory focuses on the study of genomic imprinting and epigenetic gene regulation in mice. To understand how genomic imprinting is regulated, the Bartolomei laboratory has examined cis-acting sequences at imprinted loci and trans-acting factors that confer and maintain allele-specific epigenetic modifications in the germline and early embryos. Moreover, we are also determining how the environment, including procedures used in Assisted Reproductive Technologies (ART) and endocrine disruptors, affect imprinting and epigenetic gene regulation.
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