NIH Director’s Wednesday Afternoon Lecture Series
We study how the pancreas normally develops and use that information to grow and develop pancreatic cells (Islets of Langerhans). Our laboratory focuses on the directed differentiation of stem cells to create functional pancreatic beta cells that can be used for research on the cause(s) of diabetes as well as exploring the use of stem cell-derived islets for transplantation.
Jeffrey Friedman studies the molecular mechanisms that regulate food intake and body weight. Genetic studies in mice led to the identification of leptin, a hormone made by fat tissue, that plays a key role in regulating weight. Current studies explore the mechanisms by which leptin controls feeding behavior and body weight. Studies to identify other key regulators are also under way.
The Cline Lab research has demonstrated the roles of a variety of activity-dependent mechanisms in controlling structural plasticity of neuronal dendrites and axons, synaptic maturation and topographic map formation. This body of work has helped to generate a comprehensive understanding of the role of experience in shaping brain development.
The page was last updated on Monday, March 23, 2015 - 3:00pm