NIH Director’s Wednesday Afternoon Lecture Series

Decoding the genome regulatory program for T-cell identity

The Rothenberg group’s research is at the interface of immunology, stem cell developmental biology, systems biology, and genomics. They study gene regulation and development of T lymphocytes, gene networks controlling hematopoietic cell fates, and mechanisms underlying the dynamics of single-cell developmental decisions. 

LINGO proteins: a new language for the mucosal barrier

The Herbert lab investigates cellular and molecular mechanisms responsible for the initiation of Type 2 immunity against gastrointestinal helminths and enteropathogenic bacteria. We are focused upon identification of novel cytokine/receptor interactions that regulate the cross-talk between epithelial and myeloid compartments leading to pathogen clearance and tissue repair.

Cell and genome organization in mitosis, development, and homeostasis

I began my research career studying how microtubules regulate various cellular processes, especially microtubule assembly, mitotic spindle assembly, and chromosome segregation. As a PhD student in Dr. Berl Oakley’s lab, my study of g-tubulin has inspired me to use biochemical approaches to investigate the mechanism of microtubule nucleation as a postdoctoral fellow in Drs. Bruce Alberts and Tim Mitchison’s labs at UCSF. This has led to the discovery of the g-tubulin ring complex (gTuRC) and the demonstration of its microtubule-nucleating activity from purified tubulins.