Current Lecture Season
All lectures are viewable live at http://videocast.nih.gov and then later archived there.
Additionally, the following lectures will be in person at Lipsett Amphitheater to a limited audience: May 4 (Namandjé Bumpus), May 11 (John Kuriyan), May 25 (Olufunmilayo Olopade), June 7 (Yishi Jin), June 8 (Yakeel Quiroz), June 15 (Gillian Griffiths), and June 29 (Ileana Cristea). Contact WALSoffice@od.nih.gov if you are interested in attending.
Our laboratory studies how micro- and nanoscale systems can be deployed to understand, diagnose, and treat human disease. In this talk, I will describe our progress in two application areas: liver disease and cancer. In the area of the liver, we are developing microtechnology tools to understand how ensembles of cells coordinate to produce tissues with emergent properties in the body. We have used this understanding to fabricate human microliver tissues in both '2D' and '3D' formats that enable us to study the pathogenesis of relapsing malaria and liver regeneration.
Leveraging the Intramural Research Program to Effect Foundational Progress in Neurodegenerative Disease
In this lecture, Dr. Singleton will cover his laboratory’s work aimed at unraveling the genetics of Parkinson’s disease. This work has resulted in the identification of a large number of causal risk variants and risk loci forming the basis for much of the current mechanistic research and providing targets for therapeutic intervention. He will discuss how genetics has evolved into highly collaborative team science, and how using the capabilities and position of the Intramural Research Program has been critically important in shaping this work.
Our research focuses on understanding the basic molecular mechanisms that regulate cell movement—in the context of wound healing, inflammation and cancer.
This lecture is postponed till fall 2022.
(This will be a remote-only lecture; see https://videocast.nih.gov/watch=44246.) Stem cells are the foundation of all mammalian life; they build and maintain our bodies throughout life. Both embryonic and adult stem cells can be used to establish "organoids," 3D structures established in a dish that recapitulate many aspects of the organ they represent. Pluripotent stem cells can be taken through the developmental steps that establish organs during embryogenesis.
(This will be a hybrid lecture, in person at Lipsett Amphitheater and on NIH VideoCast.) The scientific goal of my laboratory is to elucidate the molecular mechanisms of cell division and size control. Our interdisciplinary approaches take advantage of in vitro systems, particularly cytoplasmic extracts prepared from eggs of the frog Xenopus laevis that reconstitute mitotic chromosome condensation and spindle assembly in vitro.
(This will be a hybrid lecture, in person at Lipsett Amphitheather and on NIH VideoCast.) Antiretroviral therapy has markedly reduced morbidity and mortality for persons living with human immunodeficiency virus (HIV). Individual tailoring of antiretroviral regimens has the potential to further improve the long-term management of HIV through the mitigation of treatment failure and drug-induced toxicities.
(This will be a hybrid lecture, in person at Lipsett Amphitheather and on NIH VideoCast.) Dr. Kuriyan’s research concerns the atomic-level structure and mechanism of the enzymes and molecular switches that carry out cellular signal transduction. His laboratory uses x-ray crystallography to determine the three-dimensional structures of proteins involved in signaling, as well as biochemical, biophysical, and cell biological analyses to elucidate mechanisms.
Whether older individuals with diabetes and obesity should be encouraged to lose weight remains controversial. Observational studies have suggested that weight loss in older adults may be associated with increased risk of mortality, but this conclusion may be due to unintentional weight loss. A randomized trial in which some individuals are assigned to a weight loss program is the best way to address the question of whether intentional efforts to lose weight are appropriate for older individuals who have diabetes and obesity.
Heterogeneity of Breast Cancer Genomes: Going Beyond Therapy to Risk Assessment and Precision Healthcare
(This will be a hybrid lecture, in person at Lipsett Amphitheather and on NIH VideoCast.) Breast cancer is the most common cancer in women, with an estimated 2.3 million new cases diagnosed in 2021 worldwide. Geographic variations in age specific incidence and mortality point to differences in etiology. Decades after discovery, the estrogen receptor remains the single most important determinant of outcomes in breast cancer but innovative and precise biology-driven approaches to therapy are being integrated into clinical practice.
The page was last updated on Monday, May 2, 2022 - 4:24pm