Targeting Aging, Longevity and Rejuvenation

Florence Mahoney Lecture on Aging | Wednesday, April 2, 2025 | 2:00 to 3:00 p.m. ET

Vadim Gladyshev, Ph.D.

Professor of Medicine

Harvard Medical School

vgladyshev@rics.bwh.harvard.edu

Website

Vadim N. Gladyshev is a professor of medicine at Brigham and Women's Hospital, Harvard Medical School, who specializes in antioxidant biology. He is known for his characterization of the human selenoproteome. He is also known for his work on the effects of aging in humans. He has conducted studies on whether organisms can acquire cellular damage from their food; the role selenium plays as a micro-nutrient with significant health benefits; In 2013 he won the NIH Pioneer Award. In 2021, he was elected member of the U. S. National Academy of Sciences.

Summary

https://videocast.nih.gov/watch=55029 

The following topics will be discussed:
(i) The nature of aging and ongoing disagreements within the field;
(ii) Longevity signatures—across species and interventions—that define the system's potential for extended lifespan, and their comparison to aging patterns;
(iii) Quantitative biomarkers of aging (epigenetic, transcriptomic, proteomic) and their applications for assessing biological age, as well as the effects of interventions and diseases;
(iv) Examples of rejuvenation at both cellular and organismal levels;
(v) Organ-specific aging clocks and the insights they provide into age-related diseases.