Of Flies and Men – Harnessing the Power of Drosophila to Decipher the Molecular Mechanisms of Neurodegeneration
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Daniela Zarnescu, Ph.D.
Associate Dean for Graduate Education and Postdoctoral Training
Penn State, College of Medicine
The Zarnescu Laboratory studies the molecular mechanisms of aging and neurodegenerative diseases with a focus on RNA processing and cellular metabolism. We use a combination of molecular, genetic, bioinformatic and pharmacological tools, and a diverse array of experimental models, including fruit flies, cultured cells and patient tissues. We also seek to develop therapeutics for neurodegenerative disorders. I will present our recent findings on modelling TDP-43 proteinopathies in ALS and FTD relevant circuits with a focus on metabolic, synaptic and signaling targets.
This page was last updated on Thursday, July 11, 2024