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NIH Office of Intramural Research

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  • About OIR
    • OIR Leadership & Staff
      • Nina F. Schor, M.D., Ph.D.
      • Roland A. Owens, Ph.D.
      • Janice Lee, D.D.S., M.D., M.S.
      • Andy Baxevanis, Ph.D.
      • Charles R. Dearolf, Ph.D.
      • Nadine Fonrose, M.A.
      • Arlyn García-Pérez, Ph.D.
      • Carl Hashimoto, Ph.D.
      • Kathryn M. Partin, Ph.D.
      • Rena Rodriguez, B.S.
      • Dierdre S. Andrews
      • Diana Gomez
      • Chanee' M. Jackson
      • Karen Nemes
      • Risa Isonaka, Ph.D.
      • Parker Ruhl, M.D., M.H.S.
      • Lisa L. Coronado, M.B.A.
      • Bonny Harbinger, Ph.D., J.D.
      • David B. Resnik, J.D., Ph.D.
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Precision Oncology Interest Group

Cancer is a constellation of diseases typified by the uncontrolled accumulation of cells. Given the diversity of the cell types that can be transformed, cancer can affect nearly every tissue and organ, and taking into account the variety of genetic variations, epigenetic influences, and environmental factors that drive the development of tumors, one quickly appreciates that any given cancer is essentially a patient-specific disease. From this perspective, precision in the treatment of cancer is essential in providing the best care for patients.

The goals of the Precision Oncology Interest Group (POIG) are:

Short term:

  • To discuss, plan, implement and execute the current CCR initiative to perform standardized genomic analyses (RNA-SEQ, exome-SEQ, methylation analysis) on a large cohort of NCI patients, with the goal of using these data to drive collaborative predictive and prognostic biomarker discovery and precision therapy strategies for improving patient outcomes.

Long term:

  • To discuss and implement best sample acquisition and management practices to learn the most from any precious patient material.
  • To discuss and implement the best technologies and informatics to help us discover candidates for targeted therapies with the goal of maximizing favorable outcomes for oncology patients.
  • To rationally design clinical trials in oncology with a focus on precise therapies that have the potential to maximize benefit and minimize side effects.

The POIG, and its attendant listserv, will aim to foster effective communication across the basic and clinical research oncology communities, to harness the translational powers of the NIH to advance precision therapy across cancers.

This POIG effort, initially proposed by Dr. Brigitte Widemann, will be co-led by Drs. Kenneth Aldape, Padma (Sheila) Rajagopal, Eytan Ruppin, Antonios Papanicolau-Sengos and Art Shaffer. Most importantly, everyone interested is most welcome and participate and contribute and your suggestions for discussion topics and invited speakers (including yourself, of course) are most welcome!

Mailing List

To join the Precision Oncology Interest Group mailing list, please visit the Precision Oncology Interest Group Listserv home page, then click the “Subscribe or Unsubscribe” link in the right sidebar.

Chairs

  • Padma Rajagopal, M.D., MPH, NCI
  • Antonios Papanicolau-Sengos, M.D., NCI

Advisors

  • Brigitte Widemann, M.D., NCI
  • Kenneth Aldape, M.D., NCI

Scientific Focus Areas

  • Cancer Biology

    View SIGs in Cancer Biology

    Learn more about Cancer Biology in the IRP

  • Clinical Research

    View SIGs in Clinical Research

    Learn more about Clinical Research in the IRP

  • Cell Biology

    View SIGs in Cell Biology

    Learn more about Cell Biology in the IRP

This page was last updated on Wednesday, November 17, 2021

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    • Chromosome Biology
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    • Developmental Biology
    • Epidemiology
    • Genetics and Genomics
    • Health Disparities
    • Immunology
    • Microbiology and Infectious Diseases
    • Molecular Biology and Biochemistry
    • Molecular Pharmacology
    • Neuroscience
    • RNA Biology
    • Social and Behavioral Sciences
    • Stem Cell Biology
    • Structural Biology
    • Systems Biology
    • Virology
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Main navigation

  • About OIR
    • OIR Leadership & Staff
    • Intramural Targeted Anti-COVID-19 (ITAC) Awards
    • DDIR Innovation Awards
    • Long-Term IRP Planning
    • OIR Offices
  • Sourcebook
    • Board of Scientific and Clinical Directors
    • Committees Advisory to the DDIR
    • Processes for Reviewing NIH Intramural Science
    • Intramural Program Oversight
    • Intramural Administrative Management Council
    • Personnel
    • Tenure in the NIH Intramural Research Program
    • Awards, Fellowships, & Grant Opportunities
    • Ethical Conduct
    • Mentoring & Training
    • Submitting Research Publications
    • Intramural Research Communications & Resources
  • Lectures & Events
    • WALS
    • NIH Research Festival
  • SIGs
    • SIGs by Name
    • SIGs by Scientific Focus Area
  • IRP Website
    • A premier environment where creative scientists conduct fundamental research for the betterment of human health – we are the IRP
    • Visit Website
  • The NIH Catalyst
    • A publication for and about the NIH intramural research community
    • Visit Website
  • NIDB
    • The NIH Intramural Database collects and disseminates information about research being performed in the Intramural Programs
    • Visit Website
  • Department of Health and Human Services
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