MicroRNAs and their regulatory effects
David Bartel, Ph.D.
Member, Whitehead Institute
Investigator, Howard Hughes Medical Institute
Professor of Biology at
Massachusetts Institute of Technology
MicroRNAs (miRNAs) are short RNAs that pair to sites within messenger RNAs (mRNAs) to down-regulate the expression of protein-coding genes. These miRNAs play critical roles in mammalian biology and disease. Indeed, because miRNAs specify the repression of most human genes, it is hard to find a disease, developmental process, or physiological state that is not influenced in some way by miRNAs. For his lecture, Dr. Bartel will present an overview of miRNAs and their regulatory roles. He will then describe the molecular consequences of miRNAs on their mRNA targets and how these consequences change as the relationship between mRNA poly(A)-tail length and translational efficiency shifts during the early embryonic development.
This page was last updated on Wednesday, August 11, 2021