Why parents matter (epigenetically): Genomic imprinting in health and disease

Wednesday, January 6, 2016 | 3:00 to 4:00 p.m. ET

Marisa Bartolomei, Ph.D.

Professor of Cell & Developmental Biology

Co-Director Epigenetics Program

University of Pennsylvania Perelman School of Medicine

bartolom@mail.med.upenn.edu

Website

Summary

The research in the Bartolomei laboratory focuses on the study of genomic imprinting and epigenetic gene regulation in mice. To understand how genomic imprinting is regulated, the Bartolomei laboratory has examined cis-acting sequences at imprinted loci and trans-acting factors that confer and maintain allele-specific epigenetic modifications in the germline and early embryos. Moreover, we are also determining how the environment, including procedures used in Assisted Reproductive Technologies (ART) and endocrine disruptors, affect imprinting and epigenetic gene regulation.