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Thinking about cancer as an infectious disease

Wednesday, May 31, 2017 - 3:00pm to 4:00pm

Speaker

Patrick S. Moore, M.D., M.P.H.
Distinguished and American Cancer Society Professor
University of Pittsburgh Cancer Institute

Summary

Infection causes 1 in 5 cancers worldwide. Many tumor suppressors, such as p53, have dual functions to prevent tumor cell growth and to inhibit viral replication. These molecules may have evolved from a primordial unicellular eukaryotic antiviral defense system that inhibited DNA synthesis and initiated programmed cell death in response to viral infection. Two cancer viruses found by our lab, Kaposi’s sarcoma herpesvirus and Merkel cell polyomavirus, provide examples of how virus targeting in a cell can be used to understand important circuits controlling tumor cell growth.


The page was last updated on Thursday, May 4, 2017 - 1:10pm