RESCHEDULED for April 28, 2021 – CFTR, the Odd ABC Transporter Responsible for Cystic Fibrosis
In support of the Office of Personal Management guidance to strengthen efforts to protect the federal workforce and to ensure continuity of operations during the COVID-19 outbreak, the NIH Director is requesting that NIH-sponsored large meetings and symposia scheduled for March and April be held virtually, postponed, or cancelled.
Dr. Chen's lecture has been rescheduled to April 28, 2021.
We study ATP-binding cassette (ABC) transporters, a diverse group of membrane proteins integral to almost every biological process. In prokaryotes, these proteins are critical for survival. In humans, ABC transporters make up one of the largest gene families, and more than a dozen genetic diseases have been traced to ABC transporter defects. ABC transporters are also central to multidrug resistance in many pathogenic bacteria and in tumor cells. By pursuing structural and mechanistic studies of ABC transporters, we hope to understand how nature utilizes the chemical energy of ATP hydrolysis to perform work – transporting substrates against their chemical gradients. Currently, we are focusing on the following questions: 1. How anti-cancer drugs are ejected by ABC transporters? 2, How antigens are transported and loaded onto MHC-I molecules? and 3, The root cause of cystic fibrosis.
The page was last updated on Thursday, April 9, 2020 - 3:46pm