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CFTR, the Odd ABC Transporter Responsible for Cystic Fibrosis

Wednesday, April 28, 2021 - 3:00pm to 4:00pm

Speaker

Jue Chen, Ph.D.
William Ford Professor
HHMI Investigator
The Rockefeller University

Summary

We study ATP-binding cassette (ABC) transporters, a diverse group of membrane proteins integral to almost every biological process. In prokaryotes, these proteins are critical for survival. In humans, ABC transporters make up one of the largest gene families, and more than a dozen genetic diseases have been traced to ABC transporter defects. ABC transporters are also central to multidrug resistance in many pathogenic bacteria and in tumor cells. By pursuing structural and mechanistic studies of ABC transporters, we hope to understand how nature utilizes the chemical energy of ATP hydrolysis to perform work – transporting substrates against their chemical gradients. Currently, we are focusing on the following questions: 1. How anti-cancer drugs are ejected by ABC transporters? 2, How antigens are transported and loaded onto MHC-I molecules? and 3, The root cause of cystic fibrosis. 


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