Therapeutic Opportunities in Glycoscience
Dr. Bertozzi is the Anne T. and Robert M. Bass Professor of Chemistry at Stanford University and an HHMI Investigator. Her laboratory studies cell–surface interactions that contribute to human health and disease with specific projects in the areas of cancer, inflammation, and bacterial infection. Her research accomplishments include launching the field of bioorthogonal chemistry and applying such reactions to in vivo imaging of cell–surface glycans, glycoproteomics platforms for cancer–biomarker discovery, and protein engineering for biotherapeutic development.
Cell–surface glycans constitute a rich biomolecular dataset that drives both normal and pathological processes. Their “readers” are glycan–binding receptors that can engage in cell–cell interactions and cell signaling. Dr. Bertozzi's research focuses on mechanistic studies of glycan–receptor biology and applications of this knowledge to new therapeutic strategies. Her recent efforts center on pathogenic glycans in the tumor microenvironment and new therapeutic modalities based on the concept of targeted degradation.
The page was last updated on Tuesday, April 5, 2022 - 10:41am