Imaging Cell Migration in Inflammation Resolution and Tissue Repair
Anna Huttenlocher is an American rheumatologist and physician-scientist known for her work in cell migration and wound healing. She is Professor of Pediatrics and Medical Microbiology and Immunology at University of Wisconsin–Madison. Her research focuses on characterizing the molecular mechanisms that regulate cell migration, and the implications of these mechanisms to human disease, including cancer metastasis and inflammation.
Cell migration plays a central role in many different disease processes including cancer, heart disease and autoimmune disease. Insight into the mechanisms that regulate cell migration will contribute to our understanding of basic cellular processes, but will also aid in the identification of new treatment strategies for a wide variety of medical conditions. Despite extensive interest in the receptors and mechanisms involved during cell migration, many fundamental questions remain unanswered. What are the mechanisms by which a cell initiates and then subsequently stops directional cell migration? How are intracellular signaling events coordinated both temporally and spatially to promote productive, directional cell movements? What are the mechanisms that regulate the migration of leukocytes into areas of inflammation? How do tumor cells invade and metastasize? Huttenlocher's research is aimed at understanding the cellular and molecular mechanisms that regulate cell migration using biochemical genetic and imaging approaches. Her lab uses state-of-the-art live imaging, biosensors and photomanipulation to examine and control polarity of cell signaling during cell migration in live animals. They also examine host-pathogen interactions in zebrafish.
This talk will focus on cell migration in interstitial tissues during tissue repair. In particular, the speaker will address mechanisms that regulate cell motility during resolution of tissue inflammation.
- To gain an understanding of cell migration in interstitial tissues
- Identification of mechanisms of inflammation resolution
- Modeling human disease in zebrafish
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