Modulating immunity through ligand-receptor engineering
Christopher Garcia, Ph.D.
Professor of Molecular and Cellular Physiology and of Structural Biology; HHMI Investigator
Stanford University School of Medicine
Welcome to the lab of Professor Chris Garcia. Our laboratory is broadly interested in cell surface receptors and their ligands. Our principal goal is to exploit mechanistic and structural information on receptor-ligand interactions to interrogate and therapeutically impact human disease. We ask how ligand recognition and signaling coordinate with the physiology of the cell using protein engineering to manipulate signaling pathways in order to control cell function and fate. The receptor systems we study play key roles in immunology, stem cell and neurobiology, and have translational relevance to immunotherapy and regenerative medicine.
Dr. Garcia will discuss insights into immunoreceptor signaling and therapeutic modulation based on structure-based protein engineering. By mainly focusing on cytokine systems but will also delve into other axes. To show the overall principles focus on the exploitation of induced proximity at the cell surface to therapeutically manipulate signaling.
This page was last updated on Wednesday, April 26, 2023