Skip to main content
NIH Office of Intramural Research

Navigation controls

  • Search
  • Menu

Main navigation

  • About OIR
    • OIR Leadership & Staff
      • Nina F. Schor, M.D., Ph.D.
      • Roland A. Owens, Ph.D.
      • Janice Lee, D.D.S., M.D., M.S.
      • Andy Baxevanis, Ph.D.
      • Charles R. Dearolf, Ph.D.
      • Nadine Fonrose, M.A.
      • Arlyn García-Pérez, Ph.D.
      • Carl Hashimoto, Ph.D.
      • Kathryn M. Partin, Ph.D.
      • Rena Rodriguez, B.S.
      • Dierdre S. Andrews
      • Diana Gomez
      • Chanee' M. Jackson
      • Karen Nemes
      • Risa Isonaka, Ph.D.
      • Parker Ruhl, M.D., M.H.S.
      • Lisa L. Coronado, M.B.A.
      • Bonny Harbinger, Ph.D., J.D.
      • David B. Resnik, J.D., Ph.D.
      • Richard G. Wyatt, M.D.
    • Intramural Targeted Anti-COVID-19 (ITAC) Awards
    • DDIR Innovation Awards
    • Long-Term IRP Planning
    • OIR Offices
  • Sourcebook
    • Board of Scientific and Clinical Directors
      • Board of Scientific and Clinical Directors Membership
      • NIH IRP Scientific Directors
      • NIH IRP Clinical Directors
      • Board of Scientific and Clinical Directors Subcommittees
    • Committees Advisory to the DDIR
      • Assembly of Scientists (AOS)
      • Committee on Scientific Conduct and Ethics (CSCE)
      • Central Tenure Committee (CTC)
      • Chairs of the Boards of Scientific Counselors
      • Tenure-Track Investigators Committee
      • Women Scientist Advisors (WSA) Committee
      • Animal Research Advisory Committee (ARAC)
      • Dual Use Research of Concern (DURC) Committee
      • Facilities Working Group
      • NIH Space Recommendation Board
      • PHS Technology Transfer Policy Board
    • Processes for Reviewing NIH Intramural Science
      • Boards of Scientific Counselors (BSC)
        • Process for Appeal to a BSC Review
      • Role and Review of Scientific Directors and Clinical Directors
      • Blue Ribbon Panel Reviews of IC Intramural Research Programs
    • Intramural Program Oversight
      • Electronic Lab Notebooks
        • Intramural Electronic Lab Notebook Policy
        • Frequently Asked Questions About the Use of ELNs at NIH
      • Human Subjects Research
      • Intramural Data Sharing
        • 2023 NIH Data Management and Sharing Policy
        • Genomic Data Sharing
        • Human Data Sharing
        • Guide to FDAAA Reporting Research Results
          • Frequently Asked Questions: NIH Clinical Trial Definition
          • Assistance Available to Help with Results Reporting to ClinicalTrials.gov
            • Points of Contact for FDAAA Compliance at ICs
      • IRP Research Security
      • Laboratory Safety
      • Management Controls Survey
    • Intramural Administrative Management Council
      • List of Council Members
      • List of Trans-NIH Committees
    • Personnel
      • IPDs and Appointment Mechanisms
        • Official List of Approved Intramural Professional Designations (IPDs)
        • Senior Investigator
        • Investigator
        • Senior Clinician
        • Senior Scientist
        • Assistant Clinical Investigator
        • Staff Clinician
        • Staff Scientist
          • Explanation of Staff Scientist Position and Titles to Academic Colleagues
        • Senior Research Assistant / Research Assistant
        • Adjunct Investigator
        • Scientist Emeritus
        • Intramural Research Training Award (IRTA) Fellow
        • Visiting Fellow
        • ORISE Senior Fellow
        • Senior Clinical Fellow
        • Clinical Fellow
        • Senior Research Fellow
        • Research Fellow
          • Independent Research Scholar Program
        • Student Opportunities
        • Contractors
        • Guest Researchers / Special Volunteers
        • Research Collaborators
      • Faculty Development
        • 2024 OITE/OIR Professional Development Curriculum for NIH Faculty
        • Senior Advisors for Faculty Development
      • Policies and Recruitment Processes
        • 5-Year / 8-Year Duration Rule
        • Addendum to On-Site Research Collaborators (RC) Policies: On-Site RC Conducting Human Subjects Research at NIH
        • Clarification on Searches for Scientific Director and Clinical Director
        • Departing Staff Request to Remove Copies of NIH Records
        • Extension Exceptions for Non-FTE Trainees for COVID-19
        • Fair Review Principles for Nominations of Staff Scientists for Associate Scientist and Senior Associate Scientist Titles
        • Guide for Avoiding Undue Foreign Interference with IRP Research
        • Guidelines for Parental/Family Excused Absence for IRTAs, CRTAs, and Visiting Fellows
        • Mandated Training for Scientific Staff Working in NIH Facilities
        • Policy for a Letter of Agreement for Staff Scientists
        • Policy for Reassignment or Early Termination of Awards to Postbaccalaureate Fellows
        • Policy for Reassignment or Early Termination of Awards to Postdoctoral Fellows
        • Policy for Reassignment or Early Termination of Awards to Predoctoral Fellows
        • Policy for Use of Contract Workers to Support Scientific Functions in the IRP
        • Policy on Use of English for Official Scientific Communication in NIH Laboratories and Branches
        • Postdoctoral Fellows (IRTA/CRTA/VF) Temporary Exceptional Extensions Policy
        • Roles of Lab and Branch Chiefs (or Equivalent)
        • Telework Policies for IRTA/CRTA and Visiting Fellows
        • Working with Displaced Title 42 Staff Scientists/Clinicians
      • Quality-of-Life Features
      • Sabbaticals
        • NIAAA Sabbatical Program
        • NEI Sabbatical Program
        • NICHD Sabbatical Program
        • PHS Foreign Work / Study Program Policy
      • Opportunities for Short Assignments / Details at the NIH
    • Tenure in the NIH Intramural Research Program
      • Tenure-Track Overview
      • Search & Selection
        • Search Process for Senior Investigators, Tenure-Track Investigators, Senior Clinicians and Senior Scientists
      • Additional Tenure-Track Policies
      • Resources
      • Policy on IC Tenure Review Committees
      • Tenure Overview
      • Search & Selection
      • Criteria for Tenure at the NIH
      • De-Tenuring Process
    • Awards, Fellowships, & Grant Opportunities
      • The Director’s Challenge Innovation Award Program
        • 2020 Director’s Challenge Awards
        • 2022 Director’s Challenge Awards
        • 2024 Director’s Challenge Awards
      • Early Career (Bridge) Awards Open to IRP Scientists
      • Eligibility of Intramural Investigators for NIH Common Fund Awards
      • K99/R00 Grant Award Information
        • Application Approval Process and Additional Information
        • K99/R00 Environment and Institutional Commitment Statement
        • Update from Scientific Directors
      • NIAID Support of Intramural Biodefense Research from ICs Other Than NIAID
    • Ethical Conduct
      • Research Misconduct
        • Anonymous Reporting of Research Misconduct Concerns
        • Taraswi Banerjee, Ph.D.
        • Alfredo R Sancho, Ph.D., M.P.H.
      • Guidelines on Conduct of Research
      • Research Ethics
        • NIH Policies
          • Intramural / Extramural Collaborations
            • NIH Staff Involvement on Extramural Awards - Cooperative Agreements
              • Opportunities for Collaborative Research at the Clinical Center (U01)
              • NIH Bench-to-Bedside Program
            • Activities with Outside Organizations
          • NIH Human Biospecimen Program
            • Frequently Asked Questions
            • List of Biospecimen Liaisons
          • Investigation of Allegations of Research Misconduct
        • NIH Guidelines
      • Authorship Guidelines and Resources
        • Authorship Resources
        • NIH IRP Authorship Conflict Resolution Process
      • Special Research Considerations
        • Dual-Use Research
        • Policy on the Ordering or Provision of Synthetic Nucleic Acids in the IRP
        • Human Stem Cell Use
          • Human Embryonic Stem Cell (hESCs) Use
          • Induced Pluripotent Stem Cells (iPSCs) Use
          • Human Embryo Research and Cloning Prohibitions
        • Policies & Procedures for Human Fetal Tissue Research
      • Responsible Conduct of Research Training
        • Instruction in Responsible Conduct of Research - Postdoc IRTA, CRTA, VF, Research Associates
          • Reproducibility Training
          • Introduction to “My Laboratory”
        • Instruction in Responsible Conduct of Research - Postbacs and GPP Students
        • Resources for Training Directors
        • Annual Review of Ethics (Case Studies)
          • Research Cases for Use by the NIH Community
            • 2021 Ethics Case Facilitator Training
      • Government Ethics
        • Guidelines for Non-FTEs (Trainees) for NIH-Related Activities, Outside Activities, and Awards
      • Bioethics
    • Mentoring & Training
      • Guide to Training and Mentoring
      • Guidelines for Mentors at NIH
      • Guidelines for Trainees at NIH
      • Guidelines for Annual Progress Review of Trainees
      • Scientific Director Policy Updates for Mentors and Trainees
      • Goals for Enhanced Mentoring in the IRP
      • FelCom Mentoring Committee
      • Mentoring Cases for Discussions
    • Submitting Research Publications
      • PubMed Central (PMC) Deposition Requirements
      • Intramural Directions for Submitting to PubMed Central via NIHMS
      • NIH Publishing Agreement Forms
        • Procedures for Non-Peer-Reviewed Publications
      • Publication and Abstract Clearance
    • Intramural Research Communications & Resources
      • Annual Reports and Bibliographies
  • Lectures & Events
    • WALS
      • About WALS
      • Current Lecture Season
      • Past Lecture Seasons & Speakers
        • Browse by Season
        • Browse by Speaker
      • Named & Honorific Lectures
        • NIH Director’s Lecture
        • Rolla E. Dyer Lecture
        • G. Burroughs Mider Lecture
        • Marshall W. Nirenberg Lecture
        • Margaret Pittman Lecture
        • J. Edward Rall Cultural Lecture
        • Astute Clinician Lecture
        • Robert S. Gordon Jr. Lecture
        • George Khoury Lecture
        • Florence Mahoney Lecture on Aging
        • William E. Paul Lecture
        • DeWitt Stetten Jr. Lecture
      • Continuing Medical Education Credits
    • NIH Research Festival
      • The NIH Research Festival is the showcase for intramural research
      • Visit Website
  • SIGs
    • SIGs by Name
    • SIGs by Scientific Focus Area
      • Biomedical Engineering and Biophysics
      • Cancer Biology
      • Cell Biology
      • Chemical Biology
      • Chromosome Biology
      • Clinical Research
      • Computational Biology
      • Developmental Biology
      • Epidemiology
      • Genetics and Genomics
      • Health Disparities
      • Immunology
      • Microbiology and Infectious Diseases
      • Molecular Biology and Biochemistry
      • Molecular Pharmacology
      • Neuroscience
      • RNA Biology
      • Social and Behavioral Sciences
      • Stem Cell Biology
      • Structural Biology
      • Systems Biology
      • Virology
  • IRP Website
    • A premier environment where creative scientists conduct fundamental research for the betterment of human health – we are the IRP
    • Visit Website
  • The NIH Catalyst
    • A publication for and about the NIH intramural research community
    • Visit Website
  • NIDB
    • The NIH Intramural Database collects and disseminates information about research being performed in the Intramural Programs
    • Visit Website

Liquid Biopsies Interest Group

image of test tube

The Liquid Biopsies (LB) Scientific Interest Group (SIG) welcomes scientists engaged or interested in any aspects of liquid biopsy research including cell free nucleic acids, proteins, circulating tumor cells and immune cells.

The aims of the Liquid Biopsies Interest Group are to: (1) foster scientific exchange; (2) communication of research (3); working towards establishing standard practices for circulating nucleic acids studies; (4) sharing and optimization of techniques.

Although cell free DNA was discovered in human plasma by scientists in the 1940s, only recently has interest in circulating nucleic acids risen in prominence. The most commonly-studied species, circulating cell-free DNA, has a very short half-life and is typically associated with the turnover of normal or diseased tissues. However, studies of cell-free nucleic acids also extend to the repertoire of circulating mitochondrial DNA, DNA of fetal or placental origin, methylated DNA, damage associated molecular patterns (DAMPs), aggregates of DNA particulates, cancer-associated circulating tumor DNA, and stable, circulating RNAs.

In September 2018, NIEHS Inflammation Faculty hosted a workshop focused on Circulating Cell-Free DNA. With almost 100 registered attendees, the focus of this workshop was to identify methods used in clinical practice that would be relevant to toxicology studies. Representation from NIH intramural labs included investigators from NHGRI, NCI, NHLBI and NIEHS. Scientific focus areas of circulating nucleic acids (CNA) research and biomarker studies discussed included: (a) identifying mechanisms of recurrence in prostate cancer; (b) earlier screening of prenatal genomic abnormalities; (c) understanding tissue damage associated with sickle cell crises; (d) monitoring stress; (e) tissue-specific exposures to environmental toxins in adults and the unborn; (f) guiding treatment of metastatic tumors; and (g) following patients diagnosed with systemic lupus erythematosus. Key areas of discussion included limitations of detection, controlling error rates in analysis, and interpretation of results with appropriate biological context.

In 2022, the SIG broadened its scope by including research on circulating tumor cells (CTCs). The presence of CTCs was first described in 1869 by the Australian physician Thomas Ashworth. However, only the development of novel, highly sensitive technologies over the past two decades allowed their study and launched their increasing importance for cancer research and diagnostics in the clinic. 

On May 13–14, 2024, our SIG held a symposium at NIH with 550 in-person attendees, 30 platform presentations, 6 career/sciences roundtable discussion groups, and nearly 100 posters. See our agenda and NIH Catalyst newsletter article, "Blood, Sweat, and Tears."

The LB-SIG will continue to provide a networking platform for CTC researchers across NIH and beyond.

Steering Committees

  1. Webinar Committee — Chair: Adam Sowalsky, NCI (adam.sowalsky@nih.gov)
    Members — 
    Ebaa Al-Obeidi (UC Davis)
    Jack Berchuck (Emory)
    Aadel Chaudhuri (Mayo Clinic)
    Kristian Cibulskis (Precede Biosciences)
    Hallie Gaitsch (NINDS)
    Kevin Gerrish (NIEHS)
    Simon Heeke (MD Anderson)
    Daniel Kim (UCSC)
    Kate Megquier (Broad Institute)
    Rhonda Newman (Thermo-Fisher)
    Bruna Pellini (Moffitt Cancer Center)
    Sarven Sabunciyan (Johns Hopkins)
    Marina Sharifi (University of Wisconsin)
    Esta Sterneck (NCI)
    Sarah Woodfield (Baylor College of Medicine)
    A variety of presentations directed towards applicable topics to include relevant journal articles, methods debate, data club (work in progress), or bioinformatics/computational discussions. Any member of the SIG is welcome to present. Membership is open to senior staff and trainees/fellows, both within NIH and at academic institutions. To request an opportunity to present in the seminar series, please send requests along with an abstract to the chair.
  2. Communications and Membership – Chair: Kayla Heyward, NCI (kayla.heyward@nih.gov)
    The communication and membership committee identifies research groups that conduct research involving cell free nucleic acids, circulating tumor cells, or other components of liquid biopsies, and invites them to join the CNA/Liquid Biopsies SIG. 

Members’ Networking Directory and LISTSERV

To become a member of the SIG and receive news and event notifications from us, join our listserv via https://list.nih.gov/cgi-bin/wa.exe?A0=NIH-CNA-SIG.

In addition, members are encouraged to add their professional information to our directory; the form is here. The current directory can be seen here and may be used for networking and finding potential collaborations.

Chair

  • Adam Sowalsky, Ph.D., NCI

Scientific Focus Areas

  • Genetics and Genomics

    View SIGs in Genetics and Genomics

    Learn more about Genetics and Genomics in the IRP

  • Cell Biology

    View SIGs in Cell Biology

    Learn more about Cell Biology in the IRP

This page was last updated on Tuesday, November 26, 2024

Main navigation

  • SIGs by Name
  • SIGs by Scientific Focus Area
    • Biomedical Engineering and Biophysics
    • Cancer Biology
    • Cell Biology
    • Chemical Biology
    • Chromosome Biology
    • Clinical Research
    • Computational Biology
    • Developmental Biology
    • Epidemiology
    • Genetics and Genomics
    • Health Disparities
    • Immunology
    • Microbiology and Infectious Diseases
    • Molecular Biology and Biochemistry
    • Molecular Pharmacology
    • Neuroscience
    • RNA Biology
    • Social and Behavioral Sciences
    • Stem Cell Biology
    • Structural Biology
    • Systems Biology
    • Virology
  • Email
  • Print
  • Share Twitter Facebook LinkedIn

Main navigation

  • About OIR
    • OIR Leadership & Staff
    • Intramural Targeted Anti-COVID-19 (ITAC) Awards
    • DDIR Innovation Awards
    • Long-Term IRP Planning
    • OIR Offices
  • Sourcebook
    • Board of Scientific and Clinical Directors
    • Committees Advisory to the DDIR
    • Processes for Reviewing NIH Intramural Science
    • Intramural Program Oversight
    • Intramural Administrative Management Council
    • Personnel
    • Tenure in the NIH Intramural Research Program
    • Awards, Fellowships, & Grant Opportunities
    • Ethical Conduct
    • Mentoring & Training
    • Submitting Research Publications
    • Intramural Research Communications & Resources
  • Lectures & Events
    • WALS
    • NIH Research Festival
  • SIGs
    • SIGs by Name
    • SIGs by Scientific Focus Area
  • IRP Website
    • A premier environment where creative scientists conduct fundamental research for the betterment of human health – we are the IRP
    • Visit Website
  • The NIH Catalyst
    • A publication for and about the NIH intramural research community
    • Visit Website
  • NIDB
    • The NIH Intramural Database collects and disseminates information about research being performed in the Intramural Programs
    • Visit Website
  • Department of Health and Human Services
  • National Institutes of Health
  • USA.gov

Footer

  • Home
  • Contact Us
  • HHS Vulnerability Disclosure
  • Web Policies and Notices
  • Site Map
  • Search