Endurance Exercise Produces a Whole-Body Multi-Organ Molecular Reaction: a MoTPAC study.
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Sue Bodine, Ph.D.
Professor Aging & Metabolism Research Program
OKLAHOMA MEDICAL RESEARCH FOUNDATION
Sue Bodine is a Professor of Medicine at the University of Iowa Carver College of Medicine. Her current research is focused on the study of the neuromuscular system and its response and adaptation to various stressors, including exercise, disuse and aging. She received her Ph.D. from the University of California, Los Angeles, and has held positions in both academia and the biotechnology industry. She worked at Regeneron Pharmaceuticals from 1996 to 2002, where she became Co-Director of the Muscle Biology Program and worked on the identification and development of targets to treat muscle atrophy. Dr. Bodine has served as an NIH study section member and Chair of the Skeletal Muscle and Exercise Physiology panel. She currently serves on the Aging Systems and Geriatrics Study Section. She has been an Associate Editor of the American Journal of Physiology, Endocrinology and Metabolism (2010-16), Journal of Applied Physiology (2011-14) and American Journal of Physiology, Cell Physiology (2016-17). She is a member of the Editorial Board of the review journal, Physiology and is currently Editor-In-Chief of the Journal of Applied Physiology. She is a Fellow and elected Councillor of the American Physiological Society.
Summary
Regular physical activity is a cornerstone of health and wellness, yet the impact of exercise on molecular signaling within and across tissues remains poorly understood. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) is funded by the NIH Common Fund and has a primary goal of developing a molecular map of the response to both acute and chronic exercise. The ultimate goal of MoTrPAC is to advance the understanding of how physical activity protects against chronic diseases and promotes overall health. MoTrPAC incorporates both clinical and preclinical studies, collecting physiological measures and tissues for analysis by multiple “omics” platforms, including genomics, transcriptomics, proteomics, lipidomics, and metabolomics. The lecture will present an overview of the experimental design of the clinical and preclinical studies, as well as preliminary data generated from the exercise studies. MoTrPAC represents the most comprehensive exercise study done to date, examining the differential molecular response to endurance and resistance exercise, as well as the impact of age and sex on the acute and adaptative response to exercise training. The preclinical rat studies have provided the ability to examine the temporal response to both acute (7 time points) and chronic (4-time points) endurance exercise in 19 tissues in both sexes at 6 and 18 months of age. These studies have identified thousands of molecular alterations in response to training across a broad range of tissues and omic platforms. Shared and specific organ and cellular responses, along with early and late temporal dynamics have been observed. This work provides an unprecedented resource for studying temporal-, sex-, and age-specific responses to exercise in both pre-clinical animal models and humans.
Learning Objectives:
1. To introduce the experimental design and goals of the Molecular Transducers of Physical Activity Consortium.
2. To provide an overview of the unique and unparalleled physiological and multi-omic data being collected in both preclinical and clinical studies in MoTrPAC.
3. To demonstrate the robust effects of acute and chronic exercise on all tissues in the body.
This page was last updated on Friday, March 6, 2026