Skip to main content
NIH Office of Intramural Research

Navigation controls

  • Search
  • Menu

Main navigation

  • About OIR
    • OIR Leadership & Staff
      • Nina F. Schor, M.D., Ph.D.
      • Roland A. Owens, Ph.D.
      • Janice Lee, D.D.S., M.D., M.S.
      • Andy Baxevanis, Ph.D.
      • Charles R. Dearolf, Ph.D.
      • Nadine Fonrose, M.A.
      • Arlyn García-Pérez, Ph.D.
      • Carl Hashimoto, Ph.D.
      • Kathryn M. Partin, Ph.D.
      • Rena Rodriguez, B.S.
      • Dierdre S. Andrews
      • Diana Gomez
      • Chanee' M. Jackson
      • Karen Nemes
      • Risa Isonaka, Ph.D.
      • Parker Ruhl, M.D., M.H.S.
      • Lisa L. Coronado, M.B.A.
      • Bonny Harbinger, Ph.D., J.D.
      • David B. Resnik, J.D., Ph.D.
      • Richard G. Wyatt, M.D.
    • Intramural Targeted Anti-COVID-19 (ITAC) Awards
    • DDIR Innovation Awards
    • Long-Term IRP Planning
    • OIR Offices
  • Sourcebook
    • Board of Scientific and Clinical Directors
      • Board of Scientific and Clinical Directors Membership
      • NIH IRP Scientific Directors
      • NIH IRP Clinical Directors
      • Board of Scientific and Clinical Directors Subcommittees
    • Committees Advisory to the DDIR
      • Assembly of Scientists (AOS)
      • Committee on Scientific Conduct and Ethics (CSCE)
      • Central Tenure Committee (CTC)
      • Chairs of the Boards of Scientific Counselors
      • Tenure-Track Investigators Committee
      • Women Scientist Advisors (WSA) Committee
      • Animal Research Advisory Committee (ARAC)
      • Dual Use Research of Concern (DURC) Committee
      • Facilities Working Group
      • NIH Space Recommendation Board
      • PHS Technology Transfer Policy Board
    • Processes for Reviewing NIH Intramural Science
      • Boards of Scientific Counselors (BSC)
        • Process for Appeal to a BSC Review
      • Role and Review of Scientific Directors and Clinical Directors
      • Blue Ribbon Panel Reviews of IC Intramural Research Programs
    • Intramural Program Oversight
      • Electronic Lab Notebooks
        • Intramural Electronic Lab Notebook Policy
        • Frequently Asked Questions About the Use of ELNs at NIH
      • Human Subjects Research
      • Intramural Data Sharing
        • 2023 NIH Data Management and Sharing Policy
        • Genomic Data Sharing
        • Human Data Sharing
        • Guide to FDAAA Reporting Research Results
          • Frequently Asked Questions: NIH Clinical Trial Definition
          • Assistance Available to Help with Results Reporting to ClinicalTrials.gov
            • Points of Contact for FDAAA Compliance at ICs
      • IRP Research Security
      • Laboratory Safety
      • Management Controls Survey
    • Intramural Administrative Management Council
      • List of Council Members
      • List of Trans-NIH Committees
    • Personnel
      • IPDs and Appointment Mechanisms
        • Official List of Approved Intramural Professional Designations (IPDs)
        • Senior Investigator
        • Investigator
        • Senior Clinician
        • Senior Scientist
        • Assistant Clinical Investigator
        • Staff Clinician
        • Staff Scientist
          • Explanation of Staff Scientist Position and Titles to Academic Colleagues
        • Senior Research Assistant / Research Assistant
        • Adjunct Investigator
        • Scientist Emeritus
        • Intramural Research Training Award (IRTA) Fellow
        • Visiting Fellow
        • ORISE Senior Fellow
        • Senior Clinical Fellow
        • Clinical Fellow
        • Senior Research Fellow
        • Research Fellow
          • Independent Research Scholar Program
        • Student Opportunities
        • Contractors
        • Guest Researchers / Special Volunteers
        • Research Collaborators
      • Faculty Development
        • 2024 OITE/OIR Professional Development Curriculum for NIH Faculty
        • Senior Advisors for Faculty Development
      • Policies and Recruitment Processes
        • 5-Year / 8-Year Duration Rule
        • Addendum to On-Site Research Collaborators (RC) Policies: On-Site RC Conducting Human Subjects Research at NIH
        • Clarification on Searches for Scientific Director and Clinical Director
        • Departing Staff Request to Remove Copies of NIH Records
        • Extension Exceptions for Non-FTE Trainees for COVID-19
        • Fair Review Principles for Nominations of Staff Scientists for Associate Scientist and Senior Associate Scientist Titles
        • Guide for Avoiding Undue Foreign Interference with IRP Research
        • Guidelines for Parental/Family Excused Absence for IRTAs, CRTAs, and Visiting Fellows
        • Mandated Training for Scientific Staff Working in NIH Facilities
        • Policy for a Letter of Agreement for Staff Scientists
        • Policy for Reassignment or Early Termination of Awards to Postbaccalaureate Fellows
        • Policy for Reassignment or Early Termination of Awards to Postdoctoral Fellows
        • Policy for Reassignment or Early Termination of Awards to Predoctoral Fellows
        • Policy for Use of Contract Workers to Support Scientific Functions in the IRP
        • Policy on Use of English for Official Scientific Communication in NIH Laboratories and Branches
        • Postdoctoral Fellows (IRTA/CRTA/VF) Temporary Exceptional Extensions Policy
        • Roles of Lab and Branch Chiefs (or Equivalent)
        • Telework Policies for IRTA/CRTA and Visiting Fellows
        • Working with Displaced Title 42 Staff Scientists/Clinicians
      • Quality-of-Life Features
      • Sabbaticals
        • NIAAA Sabbatical Program
        • NEI Sabbatical Program
        • NICHD Sabbatical Program
        • PHS Foreign Work / Study Program Policy
      • Opportunities for Short Assignments / Details at the NIH
    • Tenure in the NIH Intramural Research Program
      • Tenure-Track Overview
      • Search & Selection
        • Search Process for Senior Investigators, Tenure-Track Investigators, Senior Clinicians and Senior Scientists
      • Additional Tenure-Track Policies
      • Resources
      • Policy on IC Tenure Review Committees
      • Tenure Overview
      • Search & Selection
      • Criteria for Tenure at the NIH
      • De-Tenuring Process
    • Awards, Fellowships, & Grant Opportunities
      • The Director’s Challenge Innovation Award Program
        • 2020 Director’s Challenge Awards
        • 2022 Director’s Challenge Awards
        • 2024 Director’s Challenge Awards
      • Early Career (Bridge) Awards Open to IRP Scientists
      • Eligibility of Intramural Investigators for NIH Common Fund Awards
      • K99/R00 Grant Award Information
        • Application Approval Process and Additional Information
        • K99/R00 Environment and Institutional Commitment Statement
        • Update from Scientific Directors
      • NIAID Support of Intramural Biodefense Research from ICs Other Than NIAID
    • Ethical Conduct
      • Research Misconduct
        • Anonymous Reporting of Research Misconduct Concerns
        • Taraswi Banerjee, Ph.D.
        • Alfredo R Sancho, Ph.D., M.P.H.
      • Guidelines on Conduct of Research
      • Research Ethics
        • NIH Policies
          • Intramural / Extramural Collaborations
            • NIH Staff Involvement on Extramural Awards - Cooperative Agreements
              • Opportunities for Collaborative Research at the Clinical Center (U01)
              • NIH Bench-to-Bedside Program
            • Activities with Outside Organizations
          • NIH Human Biospecimen Program
            • Frequently Asked Questions
            • List of Biospecimen Liaisons
          • Investigation of Allegations of Research Misconduct
        • NIH Guidelines
      • Authorship Guidelines and Resources
        • Authorship Resources
        • NIH IRP Authorship Conflict Resolution Process
      • Special Research Considerations
        • Dual-Use Research
        • Policy on the Ordering or Provision of Synthetic Nucleic Acids in the IRP
        • Human Stem Cell Use
          • Human Embryonic Stem Cell (hESCs) Use
          • Induced Pluripotent Stem Cells (iPSCs) Use
          • Human Embryo Research and Cloning Prohibitions
        • Policies & Procedures for Human Fetal Tissue Research
      • Responsible Conduct of Research Training
        • Instruction in Responsible Conduct of Research - Postdoc IRTA, CRTA, VF, Research Associates
          • Reproducibility Training
          • Introduction to “My Laboratory”
        • Instruction in Responsible Conduct of Research - Postbacs and GPP Students
        • Resources for Training Directors
        • Annual Review of Ethics (Case Studies)
          • Research Cases for Use by the NIH Community
            • 2021 Ethics Case Facilitator Training
      • Government Ethics
        • Guidelines for Non-FTEs (Trainees) for NIH-Related Activities, Outside Activities, and Awards
      • Bioethics
    • Mentoring & Training
      • Guide to Training and Mentoring
      • Guidelines for Mentors at NIH
      • Guidelines for Trainees at NIH
      • Guidelines for Annual Progress Review of Trainees
      • Scientific Director Policy Updates for Mentors and Trainees
      • Goals for Enhanced Mentoring in the IRP
      • FelCom Mentoring Committee
      • Mentoring Cases for Discussions
    • Submitting Research Publications
      • PubMed Central (PMC) Deposition Requirements
      • Intramural Directions for Submitting to PubMed Central via NIHMS
      • NIH Publishing Agreement Forms
        • Procedures for Non-Peer-Reviewed Publications
      • Publication and Abstract Clearance
    • Intramural Research Communications & Resources
      • Annual Reports and Bibliographies
  • Lectures & Events
    • WALS
      • About WALS
      • Current Lecture Season
      • Past Lecture Seasons & Speakers
        • Browse by Season
        • Browse by Speaker
      • Named & Honorific Lectures
        • NIH Director’s Lecture
        • Rolla E. Dyer Lecture
        • G. Burroughs Mider Lecture
        • Marshall W. Nirenberg Lecture
        • Margaret Pittman Lecture
        • J. Edward Rall Cultural Lecture
        • Astute Clinician Lecture
        • Robert S. Gordon Jr. Lecture
        • George Khoury Lecture
        • Florence Mahoney Lecture on Aging
        • William E. Paul Lecture
        • DeWitt Stetten Jr. Lecture
      • Continuing Medical Education Credits
    • NIH Research Festival
      • The NIH Research Festival is the showcase for intramural research
      • Visit Website
  • SIGs
    • SIGs by Name
    • SIGs by Scientific Focus Area
      • Biomedical Engineering and Biophysics
      • Cancer Biology
      • Cell Biology
      • Chemical Biology
      • Chromosome Biology
      • Clinical Research
      • Computational Biology
      • Developmental Biology
      • Epidemiology
      • Genetics and Genomics
      • Health Disparities
      • Immunology
      • Microbiology and Infectious Diseases
      • Molecular Biology and Biochemistry
      • Molecular Pharmacology
      • Neuroscience
      • RNA Biology
      • Social and Behavioral Sciences
      • Stem Cell Biology
      • Structural Biology
      • Systems Biology
      • Virology
  • IRP Website
    • A premier environment where creative scientists conduct fundamental research for the betterment of human health – we are the IRP
    • Visit Website
  • The NIH Catalyst
    • A publication for and about the NIH intramural research community
    • Visit Website
  • NIDB
    • The NIH Intramural Database collects and disseminates information about research being performed in the Intramural Programs
    • Visit Website

The structural basis of ebola viral pathogenesis

NIH Director’s Lecture | Wednesday, November 6, 2013 | 3:00 to 4:00 p.m. ET

Erica Ollmann Saphire, Ph.D.

Professor, Department of Immunology and Microbial Science

The Scripps Research Institute

erica@scripps.edu

Website

Erica Ollmann Saphire studies the molecular basis of viral pathogenesis focusing on filoviruses, arenaviruses, and the immune response against them. Her work has identified structures of viral surface glycoproteins, mapped the binding sites of key neutralizing antibodies, provided the only available structure of the intact human Immunoglobulin G (IgG), revealed molecular mechanisms of innate immunosuppression by different virus families, and illustrated genome binding and matrix assembly. Most recently, her lab has demonstrated that certain proteins, like the Ebola virus matrix, arrange into different structures in order to extend the functional complexity of their compact genomes. Dr. Saphire has received many awards recognizing her work including the Presidential Early Career Award in Science and Engineering and the Investigators in the Pathogenesis of Infectious Disease and Career Awards in the Biomedical Sciences from the Burroughs Wellcome Fund. In addition to her work in structural biology, she directs the Viral Hemorrhagic Fevers Immunotherapeutics Consortium and is on the Scientific Leadership Board of the Global Virus Network.

Summary

Dr. Saphire’s lab studies viruses with compact genomes that encode just four to seven genes each. Viruses with limited genomes offer a defined landscape of possible protein-protein interactions. Each protein is critical—many are obligated to perform multiple functions and some rearrange their structures to achieve those new functions. As a result, these few polypeptides accomplish a surprisingly complex set of biological functions including immune evasion, receptor recognition, cell entry, transcription, translation, assembly and exit. Dr. Saphire systematically analyzes the structures and functions of each protein encodes by the virus to gain fundamental insights into the biology of entry, immune evasion, and assembly, and to decipher the collaborative roles of these proteins in pathogenesis. In this lecture, Dr. Saphire will illustrate the molecular function throughout the viral life cycle: how the Ebola virus glycoprotein remodels itself during viral entry and how this remodeling affects the antibody response; how the Ebola and Lassa viruses suppress host innate immune signaling; and how the Ebola matrix protein assembles into one structure to bud new virions and into a different conformation to bind RNA and control transcription inside infected cells.

This page was last updated on Wednesday, August 11, 2021

WALS navigation

  • About WALS
  • Current Lecture Season
  • Past Lecture Seasons & Speakers
    • Browse by Season
    • Browse by Speaker
  • Named & Honorific Lectures
    • NIH Director’s Lecture
    • Rolla E. Dyer Lecture
    • G. Burroughs Mider Lecture
    • Marshall W. Nirenberg Lecture
    • Margaret Pittman Lecture
    • J. Edward Rall Cultural Lecture
    • Astute Clinician Lecture
    • Robert S. Gordon Jr. Lecture
    • George Khoury Lecture
    • Florence Mahoney Lecture on Aging
    • William E. Paul Lecture
    • DeWitt Stetten Jr. Lecture
  • Continuing Medical Education Credits
WALS 2024–2025 WALS Season season poster

WALS

  • View WALS Videocasts
  • Follow WALS on X
  • Email
  • Print
  • Share Twitter Facebook LinkedIn

Main navigation

  • About OIR
    • OIR Leadership & Staff
    • Intramural Targeted Anti-COVID-19 (ITAC) Awards
    • DDIR Innovation Awards
    • Long-Term IRP Planning
    • OIR Offices
  • Sourcebook
    • Board of Scientific and Clinical Directors
    • Committees Advisory to the DDIR
    • Processes for Reviewing NIH Intramural Science
    • Intramural Program Oversight
    • Intramural Administrative Management Council
    • Personnel
    • Tenure in the NIH Intramural Research Program
    • Awards, Fellowships, & Grant Opportunities
    • Ethical Conduct
    • Mentoring & Training
    • Submitting Research Publications
    • Intramural Research Communications & Resources
  • Lectures & Events
    • WALS
    • NIH Research Festival
  • SIGs
    • SIGs by Name
    • SIGs by Scientific Focus Area
  • IRP Website
    • A premier environment where creative scientists conduct fundamental research for the betterment of human health – we are the IRP
    • Visit Website
  • The NIH Catalyst
    • A publication for and about the NIH intramural research community
    • Visit Website
  • NIDB
    • The NIH Intramural Database collects and disseminates information about research being performed in the Intramural Programs
    • Visit Website
  • Department of Health and Human Services
  • National Institutes of Health
  • USA.gov

Footer

  • Home
  • Contact Us
  • HHS Vulnerability Disclosure
  • Web Policies and Notices
  • Site Map
  • Search