Skip to main content
NIH Office of Intramural Research

Navigation controls

  • Search
  • Menu

Main navigation

  • About OIR
    • OIR Leadership & Staff
      • Nina F. Schor, M.D., Ph.D.
      • Richard G. Wyatt, M.D.
      • Janice Lee, D.D.S., M.D., M.S.
      • Andy Baxevanis, Ph.D.
      • Charles R. Dearolf, Ph.D.
      • Nadine Fonrose, M.A.
      • Arlyn García-Pérez, Ph.D.
      • Carl Hashimoto, Ph.D.
      • Roland A. Owens, Ph.D.
      • Kathryn M. Partin, Ph.D.
      • Rena Rodriguez, B.S.
      • Dierdre S. Andrews
      • Diana Gomez
      • Chanee' M. Jackson
      • Margaret McBurney, M.B.A.
      • Karen Nemes
      • Lisa L. Coronado, M.B.A.
      • Dan Fogarty, M.A., FACHE
      • Bonny Harbinger, Ph.D., J.D.
      • David B. Resnik, J.D., Ph.D.
      • Mark L. Rohrbaugh, Ph.D., J.D.
      • Parker Ruhl, M.D., M.H.S.
    • Diversity & Inclusion
    • Intramural Targeted Anti-COVID-19 (ITAC) Awards
    • DDIR Innovation Awards
    • Long-Term IRP Planning
    • OIR Offices
  • Sourcebook
    • Intramural COVID-19 Guidance and Resources
      • IRP Repository for COVID-19 Samples
      • Rapid Review of Human Subjects Research Related to the SARS-CoV-2 Pandemic
      • Donating Personal Protective Equipment (PPE) and COVID-19 Testing Supplies
      • Exceptional Use of IC Funds for Per Diem Quarantine for Non-FTE Trainees (VF/IRTA/CRTA)
      • Student IRTA/CRTA and Student Special Volunteers
      • Extension Exceptions for Non-FTE Trainees for COVID-19
      • 2020 Virtual Postbac Poster Day
    • Board of Scientific Directors
      • Board of Scientific Directors Membership
      • Board of Scientific Directors Sub-Committees
    • Committees Advisory to the DDIR
      • Advisory Committee to the DDIR
      • Assembly of Scientists (AOS)
      • Committee on Scientific Conduct and Ethics (CSCE)
      • Central Tenure Committee (CTC)
      • Chairs of the Boards of Scientific Counselors
      • Tenure-Track Investigators Committee
      • Training Directors Committee
      • Fellows Committee (FelCom)
      • Office of Intramural Training and Education (OITE) Steering Committee
      • PostBac Committee
      • Senior Biomedical Research Service (SBRS) Policy Board
      • Women Scientist Advisors (WSA) Committee
      • Human Subjects Research Advisory Committee (HSRAC)
      • Animal Research Advisory Committee (ARAC)
      • Dual Use Research of Concern (DURC) Committee
      • NIH Intramural Embryonic Stem Cell Research Oversight (ESCRO) Committee
      • Facilities Working Group
      • NIH Space Recommendation Board
      • PHS Technology Transfer Policy Board
    • Processes for Reviewing NIH Intramural Science
      • Boards of Scientific Counselors (BSC)
        • Addendum to BSC Policies and Procedures
      • Blue Ribbon Panel Reviews of IC Intramural Research Programs
      • Role and Review of Scientific Directors and Clinical Directors
    • Intramural Program Oversight
      • Human Subjects Research
        • NIH IRP Clinical Directors
      • Intramural Data Sharing
        • 2023 NIH Data Management and Sharing Policy
        • Genomic Data Sharing
        • Human Data Sharing
        • Guide to FDAAA Reporting Research Results
          • Frequently Asked Questions: NIH Clinical Trial Definition
          • Assistance Available to Help with Results Reporting to ClinicalTrials.gov
            • Points of Contact for FDAAA Compliance at ICs
      • Laboratory Safety
      • Management Controls Survey
    • Intramural Administrative Management Council
      • List of Council Members
      • List of Trans-NIH Committees
    • Personnel
      • IPDs and Appointment Mechanisms
        • Official List of Approved Intramural Professional Designations (IPDs)
        • Senior Investigator
        • Investigator
        • Senior Clinician
        • Senior Scientist
        • Assistant Clinical Investigator
        • Staff Clinician
        • Staff Scientist
        • Senior Research Assistant / Research Assistant
        • Adjunct Investigator
        • Scientist Emeritus
        • Intramural Research Training Award (IRTA) Fellow
        • Visiting Fellow
        • ORISE Senior Fellow
        • Senior Clinical Fellow
        • Clinical Fellow
        • Senior Research Fellow
        • Research Fellow
          • Independent Research Scholar Program
        • Student Opportunities
        • Contractors
        • Guest Researchers / Special Volunteers
        • Research Collaborators
      • Policies and Recruitment Processes
        • 5-Year / 8-Year Duration Rule
        • Departing Staff Request to Remove Copies of NIH Records
        • Example IC Check Sheets / Checklists
        • Exceptional Extensions of IRTA and Visiting Fellowships to a 6th Year
        • Fair Review Principles for Nominations of Staff Scientists for Associate Scientist and Senior Associate Scientist Titles
        • Guide for Avoiding Undue Foreign Interference with IRP Research
        • Guidelines for Parental/Family Excused Absence for IRTAs, CRTAs, and Visiting Fellows
        • Keep The Thread Policy
        • Mandated Training for Scientific Staff Working in NIH Facilities
        • Policy for Reassignment or Early Termination of Awards to Postbaccalaureate Fellows
        • Policy for Reassignment or Early Termination of Awards to Postdoctoral Fellows
        • Policy for Reassignment or Early Termination of Awards to Predoctoral Fellows
        • Policy for Use of Contract Workers to Support Scientific Functions in the IRP
        • Policy on Use of English for Official Scientific Communication in NIH Laboratories and Branches
        • Postdoctoral Fellows (IRTA/CRTA/VF) Temporary Exceptional Extensions Policy
        • Roles of Lab and Branch Chiefs (or Equivalent)
        • Telework Policies for IRTA/CRTA and Visiting Fellows
        • Working with Displaced Title 42 Staff Scientists/Clinicians
      • IRP Demographics
        • Intramural Research Program Personnel Demographics (End FY22)
        • Foreign Nationals in the Intramural Research Program (End FY22)
        • Intramural Research Program Personnel Demographics (End FY21)
        • Foreign Nationals in the Intramural Research Program (End FY21)
        • Intramural Research Program Personnel Demographics (End FY20)
        • Foreign Nationals in the Intramural Research Program (End FY20)
        • Intramural Research Program Personnel Demographics (End FY19)
        • Foreign Nationals in the Intramural Research Program (End FY19)
        • Intramural Research Program Personnel Demographics (End FY18)
        • Foreign Nationals in the Intramural Research Program (End FY18)
        • Intramural Research Program Personnel Demographics (End FY17)
        • Foreign Nationals in the Intramural Research Program (End FY17)
        • Intramural Research Program Personnel Demographics (End FY16)
        • Foreign Nationals in the Intramural Research Program (End FY16)
      • Quality-of-Life Features
      • Sabbaticals
        • NIAAA Sabbatical Program
        • NEI Sabbatical Program
        • NICHD Sabbatical Program
        • PHS Foreign Work / Study Program Policy
      • Opportunities for Short Assignments / Details at the NIH
    • Tenure in the NIH Intramural Research Program
      • Tenure-Track Overview
      • Search & Selection
        • Search Process for Senior Investigators, Tenure-Track Investigators, Senior Clinicians and Senior Scientists
        • Role of Search Committee Members
      • Additional Tenure-Track Policies
      • Resources
      • Policy on IC Tenure Review Committees
      • Tenure Overview
      • Search & Selection
      • Criteria for Tenure at the NIH
      • Statement About PI Involvement in Diversity, Equity, Inclusion, and Accessibility
      • De-Tenuring Process
    • Awards, Fellowships, & Grant Opportunities
      • The Director’s Challenge Innovation Award Program
        • 2020 Director’s Challenge Awards
        • 2022 Director’s Challenge Awards
      • Early Career (Bridge) Awards Open to IRP Scientists
      • Eligibility of Intramural Investigators for NIH Common Fund Awards
      • K99/R00 Grant Award Information
        • Application Approval Process and Additional Information
        • K99/R00 Environment and Institutional Commitment Statement
        • Update from Scientific Directors
      • NIAID Support of Intramural Biodefense Research from ICs Other Than NIAID
    • Ethical Conduct
      • Research Misconduct
        • Anonymous Reporting of Research Misconduct Concerns
        • Taraswi Banerjee, Ph.D.
        • Alfredo R Sancho, Ph.D., M.P.H.
      • Guidelines on Conduct of Research
      • Research Ethics
        • NIH Policies
          • Intramural / Extramural Collaborations
            • NIH Staff Involvement on Extramural Awards - Cooperative Agreements
              • Opportunities for Collaborative Research at the Clinical Center (U01)
              • NIH Bench-to-Bedside Program
            • Activities with Outside Organizations
          • Investigation of Allegations of Research Misconduct
        • NIH Guidelines
          • Guide for Human Biospecimen Storage and Tracking
            • Frequently Asked Questions
            • List of Biospecimen Liaisons
      • Special Research Considerations
        • Dual-Use Research
        • Human Stem Cell Use
          • Human Embryonic Stem Cell (hESCs) Use
          • Induced Pluripotent Stem Cells (iPSCs) Use
          • Human Embryo Research and Cloning Prohibitions
        • Policies & Procedures for Human Fetal Tissue Research
          • Policies on the Acquisition and Use of HFT
          • Procedures for Obtaining HFT
      • Responsible Conduct of Research Training
        • Instruction in Responsible Conduct of Research - Postdoc IRTA, CRTA, VF, Research Associates
          • Reproducibility Training
          • Introduction to “My Laboratory”
        • Instruction in Responsible Conduct of Research - Postbacs and GPP Students
        • Resources for Training Directors
        • Annual Review of Ethics (Case Studies)
          • Research Cases for Use by the NIH Community
            • 2021 Ethics Case Facilitator Training
        • Processes for Authorship Dispute Resolution
      • Government Ethics
        • Guidelines for Non-FTEs (Trainees) for NIH-Related Activities, Outside Activities, and Awards
      • Bioethics
    • Mentoring & Training
      • Guide to Training and Mentoring
      • Guidelines for Mentors at NIH
      • Guidelines for Trainees at NIH
      • Guidelines for Annual Progress Review of Trainees
      • Scientific Director Policy Updates for Mentors and Trainees
      • Goals for Enhanced Mentoring in the IRP
      • FelCom Mentoring Committee
      • The DDIR Implementation Plan in Response to the FelCom Subcommittee Report on Mentoring
      • Mentoring Cases for Discussions
    • Submitting Research Publications
      • PubMed Central (PMC) Deposition Requirements
      • Intramural Directions for Submitting to PubMed Central via NIHMS
      • NIH Publishing Agreement Forms
        • Procedures for Non-Peer-Reviewed Publications
      • Publication and Abstract Clearance
    • Intramural Research Communications & Resources
      • Annual Reports and Bibliographies
  • WALS
    • About WALS
    • Current Lecture Season
    • Past Lecture Seasons & Speakers
      • Browse by Season
      • Browse by Speaker
    • Named & Honorific Lectures
      • NIH Director’s Lecture
      • Rolla E. Dyer Lecture
      • G. Burroughs Mider Lecture
      • Marshall W. Nirenberg Lecture
      • Margaret Pittman Lecture
      • J. Edward Rall Cultural Lecture
      • Astute Clinician Lecture
      • Robert S. Gordon Jr. Lecture
      • George Khoury Lecture
      • Florence Mahoney Lecture on Aging
      • William E. Paul Lecture
      • DeWitt Stetten Jr. Lecture
    • WALS Lunch Request
    • Continuing Medical Education Credits
  • SIGs
    • SIGs by Name
    • SIGs by Scientific Focus Area
      • Biomedical Engineering and Biophysics
      • Cancer Biology
      • Cell Biology
      • Chemical Biology
      • Chromosome Biology
      • Clinical Research
      • Computational Biology
      • Developmental Biology
      • Epidemiology
      • Genetics and Genomics
      • Health Disparities
      • Immunology
      • Microbiology and Infectious Diseases
      • Molecular Biology and Biochemistry
      • Molecular Pharmacology
      • Neuroscience
      • RNA Biology
      • Social and Behavioral Sciences
      • Stem Cell Biology
      • Structural Biology
      • Systems Biology
      • Virology
  • IRP Website
    • A premier environment where creative scientists conduct fundamental research for the betterment of human health – we are the IRP
    • Visit Website
  • NIH Research Festival
    • The NIH Research Festival is the showcase for intramural research
    • Visit Website
  • The NIH Catalyst
    • A publication for and about the NIH intramural research community
    • Visit Website
  • NIDB
    • The NIH Intramural Database collects and disseminates information about research being performed in the Intramural Programs
    • Visit Website

2015–2016

WALS 2015–2016 season poster

Tools for analyzing and repairing complex biological systems

Edward Boyden, Ph.D.
Massachusetts Institute of Technology
Wednesday, September 2, 2015 at 3 p.m. ET
NIH Director’s Lecture

The goal of the Boyden laboratory is to achieve ground truth understandings of complex biological systems, including entire cells and entire brains, and to use such insights to improve the human condition through novel inventions and therapeutics. To make this possible, Dr. Boyden and his colleagues are currently creating technologies that enable comprehensive observation and control of biological systems, aiming for molecular precision, millisecond resolution, and whole organ scale.

Aquaporin water channels—from transfusion medicine to malaria

Peter Agre, M.D.
Johns Hopkins Malaria Research Institute
Wednesday, September 9, 2015 at 3 p.m. ET

Biochemical analysis of the Rhesus blood group antigen led to the serendipitous discovery of AQP1, the first molecular water channel. Found throughout nature, aquaporin water channels confer high water permeability to cell membranes. AQP1 has been characterized biophysically, and the atomic structure of AQP1 is known. Identification of the Colton blood group antigen on the extracellular domain of AQP1 allowed identification of rare individuals who are AQP1-null and manifest a subclinical form of nephrogenic diabetes insipidus. Thirteen homologous proteins exist in humans.

The AML genome(s): Mutations in four dimensions

Timothy J. Ley, M.D.
Washington University School of Medicine
Wednesday, September 30, 2015 at 3 p.m. ET
Marshall W. Nirenberg Lecture

For many years, Dr. Ley’s laboratory has used mouse models of acute myeloid leukemia (AML) to establish key principles of AML pathogenesis. The lab established that the initiating event for Acute Promyelocytic Leukemia is the PML-RARA fusion gene created by the t(15;17) that is found in nearly all patients with this disease. The roles of cooperating mutations and the cellular milieu for APL pathogenesis have also been established.

The zebrafish guide to tuberculosis

Lalita Ramakrishnan, Ph.D.
University of Cambridge
Wednesday, October 7, 2015 at 3 p.m. ET

We have developed the zebrafish as a surrogate model to study human tuberculosis. The optical transparency combined with the genetic tractability of this model have proved to be powerful and have allowed us to make surprising discoveries about tuberculosis pathogenesis, immunity, and drug tolerance that suggest completely new approaches to treatment. These discoveries and their application to human tuberculosis treatment will be discussed.

Challenges and promises of RNA diagnostics

Thomas Tuschl, Ph.D.
The Rockefeller University
Wednesday, October 14, 2015 at 3 p.m. ET

There is an increasing need in life and medical sciences to determine gene sequence and gene expression in cells and tissues including pathogenic organisms and viruses under normal and disease conditions as well as organismal development. The limitations in diagnostic and prognostic tools have also triggered interests in RNA present in extracellular fluid such as plasma and urine.

Form meets function: Structurally diverse cilia and their roles in sensory signaling

Piali Sengupta, Ph.D.
Brandeis University
Wednesday, October 21, 2015 at 3 p.m. ET
DeWitt Stetten Jr. Lecture

Primary cilia are microtubule-based organelles that are now known to be present on nearly all differentiated cell types in metazoans. Cilia house signaling molecules that transduce environmental cues and regulate cellular homeostasis and organismal development. Disruption of cilia structure or function is linked with a plethora of diseases termed ciliopathies, many of which are characterized by sensory defects.

SPECIAL TUESDAY LECTURE – Functional dynamics of the gut microbiome in health and disease

Claire Fraser, Ph.D.
University of Maryland School of Medicine
Tuesday, October 27, 2015 at 3 p.m. ET
Rolla E. Dyer Lecture

Current research interests are focused on characterization of the structure and function of the microbial communities that are found in the human environment, as part of the NIH-funded Human Microbiome Project, including projects specifically focused on obesity, metabolic syndrome, inflammatory bowel disease, the interactions between the human immune response and the gut microbiome, and the impact of probiotics on the structure and function of the intestinal microbiome.

Relief from severe depression and suicidal ideation within hours: from synapses to symptoms

Carlos Zarate, M.D.
National Institute of Mental Health
Wednesday, November 4, 2015 at 3 p.m. ET
Astute Clinician Lecture

Dr. Zarate’s current research focus is on developing novel medications for treatment-resistant depression and bipolar disorder. His areas of expertise include biological and pharmacological aspects of mood disorders in adults. Dr. Zarate’s group conducts proof-of-concept studies utilizing novel compounds and biomarkers (magnetoencephalography [MEG] and polysomnography [PSG], positron emission tomography, functional MRI and magnetic resonance spectroscopy [MRS]) to identify potentially relevant drug targets and biosignatures of treatment response.

Bugs, drugs, and Star Trek!

Sanjay Jain, M.D.
Johns Hopkins University
Wednesday, November 18, 2015 at 3 p.m. ET

Current tools to diagnose and monitor infections are dependent upon sampling suspected sites and then performing culture or molecular techniques. This approach is invasive and is often dangerous, time consuming, and subject to incorrect sampling and contamination. Molecular imaging is a powerful, noninvasive tool that can rapidly provide three-dimensional views of disease processes deep within the body. Moreover, it has the fundamental advantage (with significant potential for clinical translation), to conduct noninvasive longitudinal assessments of the same patient.

Imaging Immunity

Ronald N. Germain, M.D., Ph.D.
National Institute of Allergy and Infectious Diseases
Wednesday, December 9, 2015 at 3 p.m. ET
G. Burroughs Mider Lecture

Over the years, Dr. Germain and his colleagues have made key contributions to our understanding of Major Histocompatibility Complex (MHC) class II molecule structure–function relationships, the cell biology of antigen processing, and the molecular basis of T cell recognition. More recently, his laboratory has been focused on the relationship between immune tissue organization and dynamic control of adaptive immunity at both the initiation and effector stages.

  • Current page1
  • Page 22
  • Page 33
  • Page 44
  • Next pageNext ›
  • Last pageLast »

This page was last updated on Tuesday, August 10, 2021

Main navigation

  • About WALS
  • Current Lecture Season
  • Past Lecture Seasons & Speakers
    • Browse by Season
    • Browse by Speaker
  • Named & Honorific Lectures
    • NIH Director’s Lecture
    • Rolla E. Dyer Lecture
    • G. Burroughs Mider Lecture
    • Marshall W. Nirenberg Lecture
    • Margaret Pittman Lecture
    • J. Edward Rall Cultural Lecture
    • Astute Clinician Lecture
    • Robert S. Gordon Jr. Lecture
    • George Khoury Lecture
    • Florence Mahoney Lecture on Aging
    • William E. Paul Lecture
    • DeWitt Stetten Jr. Lecture
  • WALS Lunch Request
  • Continuing Medical Education Credits
WALS 2022–2023 season poster

WALS

  • View WALS Videocasts
  • Follow WALS on Twitter
  • Email
  • Print
  • Share Twitter Facebook LinkedIn

Main navigation

  • About OIR
    • OIR Leadership & Staff
    • Diversity & Inclusion
    • Intramural Targeted Anti-COVID-19 (ITAC) Awards
    • DDIR Innovation Awards
    • Long-Term IRP Planning
    • OIR Offices
  • Sourcebook
    • Intramural COVID-19 Guidance and Resources
    • Board of Scientific Directors
    • Committees Advisory to the DDIR
    • Processes for Reviewing NIH Intramural Science
    • Intramural Program Oversight
    • Intramural Administrative Management Council
    • Personnel
    • Tenure in the NIH Intramural Research Program
    • Awards, Fellowships, & Grant Opportunities
    • Ethical Conduct
    • Mentoring & Training
    • Submitting Research Publications
    • Intramural Research Communications & Resources
  • WALS
    • About WALS
    • Current Lecture Season
    • Past Lecture Seasons & Speakers
    • Named & Honorific Lectures
    • WALS Lunch Request
    • Continuing Medical Education Credits
  • SIGs
    • SIGs by Name
    • SIGs by Scientific Focus Area
  • IRP Website
    • A premier environment where creative scientists conduct fundamental research for the betterment of human health – we are the IRP
    • Visit Website
  • NIH Research Festival
    • The NIH Research Festival is the showcase for intramural research
    • Visit Website
  • The NIH Catalyst
    • A publication for and about the NIH intramural research community
    • Visit Website
  • NIDB
    • The NIH Intramural Database collects and disseminates information about research being performed in the Intramural Programs
    • Visit Website
  • Department of Health and Human Services
  • National Institutes of Health
  • USA.gov

Footer

  • Home
  • Contact Us
  • HHS Vulnerability Disclosure
  • Web Policies and Notices
  • Site Map
  • Search