POSTPONED TILL FALL — Mutant p53 Activities in Mouse Tumor Models
Research in the Lozano Lab has been focused on understanding the functional mechanism of cancer associated genes by generating mouse models. They have a long-standing interest in p53 gene as the most mutated gene in cancer. Mutation of the p53 gene is a critical event in the elaboration of many tumors of diverse origin. The p53 protein is activated in response to DNA damage, serving as a checkpoint in the elimination or repair of cells with damaged DNA. Alterations in components of the p53 pathway, such as amplification of the Mdm2 gene, which encodes a p53 inhibitor, also contributes to tumorigenesis. The overall goal of the laboratory is to understand the signals that regulate the p53 pathway and the consequences of expressing wild-type or mutant p53.
This lecture has been rescheduled for October 12, 2022.
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