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POSTPONED TILL FALL — Mutant p53 Activities in Mouse Tumor Models

Wednesday, March 2, 2022 - 3:00pm to 4:00pm


Guillermina Lozano, Ph.D.
Professor, Department of Genetics, Division of Basic Sciences
University of Texas MD Anderson Cancer Center

Research in the Lozano Lab has been focused on understanding the functional mechanism of cancer associated genes by generating mouse models. They have a long-standing interest in p53 gene as the most mutated gene in cancer. Mutation of the p53 gene is a critical event in the elaboration of many tumors of diverse origin. The p53 protein is activated in response to DNA damage, serving as a checkpoint in the elimination or repair of cells with damaged DNA. Alterations in components of the p53 pathway, such as amplification of the Mdm2 gene, which encodes a p53 inhibitor, also contributes to tumorigenesis. The overall goal of the laboratory is to understand the signals that regulate the p53 pathway and the consequences of expressing wild-type or mutant p53.


This lecture has been rescheduled for October 12, 2022.

The page was last updated on Friday, February 18, 2022 - 2:22pm