SCN2A-Related Autism and Epilepsy: From Molecular and Circuit Mechanisms to Genetic Medicines
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Yang Yang, Ph.D.
Jack and Barbara McCoy associate professor in the Department of Medicinal Chemistry and Molecular Pharmacology
Purdue University College of Pharmacy; HHMI
Yang Yang, Ph.D., is the Jack and Barbara McCoy Associate Professor in the Borch Department of Medicinal Chemistry and Molecular Pharmacology at Purdue University. His research advances precision medicine for genetic neurological disorders, with particular focus on autism, epilepsy, chronic pain, and disorders caused by mutations in voltage-gated sodium channels. Using mouse models, human stem cell-derived neurons, brain organoids, and genomic technologies, Dr. Yang investigates how disease-causing variants alter neuronal and neuroimmune function. His laboratory is also developing mutation-specific therapies, including gene replacement and CRISPR-based genome editing, with the goal of translating mechanistic discoveries into treatments for severe neurodevelopmental disorders.
This page was last updated on Wednesday, August 12, 2026