Brenda Gallie M.D., FRCSC, CM, OOnt University of Toronto
eCancerCareRB (eCCRB) has facilitated retinoblastoma circle of care communication and research at SickKids since 2001 by collecting and visually displaying point-of-care retinoblastoma data, including fundus drawings.
Jonathan Kipnis, Ph.D. Washington University in St. Louis, Department of Pathology & Immunology
Immune cells and their derived molecules have major impact on brain function. Mice deficient in adaptive immunity have impaired cognitive and social function compared to that of wild-type mice. Importantly, replenishment of the T cell compartment in immune deficient mice restored proper brain function. Despite the robust influence on brain function, T cells are not found within the brain parenchyma, a fact that only adds more mystery into these enigmatic interactions between T cells and the brain.
Bita Moghaddam, Ph.D. Oregon Health & Science University
Psychosis is a hallmark of schizophrenia. It typically emerges in late adolescence and is associated with striatal dopamine abnormalities. Most genes implicated in the risk for schizophrenia involve ubiquitous targets that do not explain the latent expression of psychosis or dopaminergic disruptions. Here, we describe an etiologically relevant mechanism for adolescent onset of dopamine abnormalities and psychosis. We focused on GRIN2A, which encodes the GluN2A subunit of the NMDA receptor.
Many proteins need to cross membranes to be secreted from cells or to be localized to intracellular organelles. In the case, of membrane proteins, some segments are translocated across the membrane, while others stay in the cytosol. Translocating a protein across a membrane is not a trivial task, as membranes are generally barriers for even small molecules and the barrier needs to be maintained during protein transport. Protein translocation across the endoplasmic reticulum (ER) membrane occurs through the Sec61 channel, which opens when a substrate arrives.
Alexis Thompson's career spans bench to beside and reached a historic milestone in 2023, with the approval of the first two gene therapies for sickle cell disease. Now Chief of the Division of Hematology at Children's Hospital of Philadelphia (CHOP), PA, USA, Thompson led clinical research on the lentiviral vector therapy lovotibeglogene autotemcel (lovo-cel) for severe sickle cell disease, approved in the USA for use in adolescents and adults.
The Brady Lab is part of the Department of Cancer Biology and the Abramson Family Cancer Research Institute in the Perelman School of Medicine at the University of Pennsylvania. Our research program at Penn is founded in a new paradigm in nutrient sensing and protein regulation, termed metalloallostery, where redox-active metals control kinase activity, and is advancing our knowledge in basic science and disease-focused areas.
Digna Velez Edwards, Ph.D., MS Vanderbilt University Medical Center
Dr. Digna Velez Edwards is a genetic epidemiologist, Professor of Obstetrics and Gynecology and Biomedical Informatics, Director of the Division of Quantitative Sciences in the Department of Obstetrics and Gynecology, Director of Women's Health Research center, Investigator of the Vanderbilt Genetics Institute, and a member of the Vanderbilt Epidemiology Center. She has doctoral training in human genetics and has a master's degree in statistics.
Ana V. Diez Roux, M.D., Ph.D., MPH Drexel Dornsife School of Public Health
Ana V. Diez Roux, MD, PHD, MPH, is Director of the Urban Health Collaborative and Distinguished University Professor of Epidemiology at the Drexel University Dornsife School of Public Health. From 2014 to 2023, she was the Dana and David Dornsife Dean of the Dornsife School of Public Health. Trained as a pediatrician in her native Buenos Aires, she completed public health training at the Johns Hopkins University School of Hygiene and Public Health. Dr.
Dr. Jaffe completed her medical education at Cornell University and the University of Pennsylvania, receiving an M.D. from the latter in 1969. After an internship at Georgetown University, she joined the NCI as a resident in anatomic pathology, and has been a senior investigator since 1974, focusing on the classification and definition of lymphoid neoplasms. She has served on the editorial boards of The American Journal of Pathology, The American Journal of Surgical Pathology, Blood, Cancer Research, and Modern Pathology, among others.
Daniela Salvemini, Ph.D. Saint Louis University, School of Medicine
Daniela Salvemini, Ph.D., is William Beaumont Professor; chair of the Department of Pharmacology and Physiology; professor in the Department of Psychiatry and Behavioral Neuroscience; and founding director of the Institute for Translational Science at Saint Louis University.
This page was last updated on Friday, August 16, 2024
