Brenda Gallie, M.D., FRCSC, CM, OOnt University of Toronto
eCancerCareRB (eCCRB) has facilitated retinoblastoma circle of care communication and research at SickKids since 2001 by collecting and visually displaying point-of-care retinoblastoma data, including fundus drawings.
Bita Moghaddam, Ph.D. Oregon Health & Science University
Psychosis is a hallmark of schizophrenia. It typically emerges in late adolescence and is associated with striatal dopamine abnormalities. Most genes implicated in the risk for schizophrenia involve ubiquitous targets that do not explain the latent expression of psychosis or dopaminergic disruptions. Here, we describe an etiologically relevant mechanism for adolescent onset of dopamine abnormalities and psychosis. We focused on GRIN2A, which encodes the GluN2A subunit of the NMDA receptor.
Many proteins need to cross membranes to be secreted from cells or to be localized to intracellular organelles. In the case, of membrane proteins, some segments are translocated across the membrane, while others stay in the cytosol. Translocating a protein across a membrane is not a trivial task, as membranes are generally barriers for even small molecules and the barrier needs to be maintained during protein transport. Protein translocation across the endoplasmic reticulum (ER) membrane occurs through the Sec61 channel, which opens when a substrate arrives.
Sickle cell disease has played many substantive roles in advances across biomedical research, yet, until recently, translation of this progress to improvement in patient outcomes have been elusive. This presentation will summarize the accomplishments over time, focusing on newer and potentially transformational therapies, acknowledging continued impediments and exploring opportunities to further make an impact on this condition.
The Brady Lab at the University of Pennsylvania focuses on two critical areas of cancer biology: the role of metal signaling and protein function in cancer development and treatment. Their research on metal signaling investigates how dietary metals and their regulation influence cellular processes, metabolic pathways, and stem cell activity, aiming to uncover how disruptions in metal balance may drive cancer.
Digna Velez Edwards, Ph.D. Vanderbilt University Medical Center
This lecture will cover current research and opportunities for women’s health research, data science, and genomics studies. Provided will be specific examples genetic studies focused on reproductive and gynecologic health from studies leveraging electronic health record biobanks.
Learning Objectives:
Understand different types of data science
Learn what research can be done with electronic health record linked biobanks
Ana V. Diez Roux, M.D., Ph.D., M.P.H. Drexel Dornsife School of Public Health
This lecture will highlight why we need continued research on the social and environmental determinants of health. It will review (1) motivation (2) evidence gaps and research needs (3) methodologic challenges and (4) implications for action and for the biomedical research enterprise more broadly. The presentation will draw on several examples, several of them NIH funded.
The lecture will briefly review the historical background of the modern classification of lymphomas. The contemporary classification of lymphomas begins with traditional pathological observations, but defines diseases based on an integration of histological features, the nature of the tumor cells as they relate to the normal immune system, genomic findings, and finally clinical presentation and course. The lecture will illustrate how observations made in the course of daily practice lead to the discovery of new diseases, and how these discoveries impact clinical management.
Daniela Salvemini, Ph.D. Saint Louis University School of Medicine
This talks aims to give an overview of the roles of sphingosine 1 phosphate (S1P) and the S1P receptor subtype 1 (S1PR1) signaling in the central nervous system in the development and maintenance of neuropathic pain states. The outcomes of such research lead us to consider that some forms of neuropathic pain states may be viewed as “sphingopathies” amenable to anti-sphingolipid based therapies.
Speech is a fundamental human behavior for communication. In this lecture, Dr. Chang will describe critical advances over the last decade in deciphering the cortical signals that underlie our ability to hear and speak words.
Learning Objectives:
To understand the cortical encoding of phonetic features in the human temporal lobe.
To understand how words are represented by cortical activity.
