Anna Huttenlocher, M.D. University of Wisconsin–Madison
This talk will focus on cell migration in interstitial tissues during tissue repair. In particular, the speaker will address mechanisms that regulate cell motility during resolution of tissue inflammation.
(This will be a remote-only lecture; see https://videocast.nih.gov/watch=44246.) Stem cells are the foundation of all mammalian life; they build and maintain our bodies throughout life. Both embryonic and adult stem cells can be used to establish “organoids,” 3D structures established in a dish that recapitulate many aspects of the organ they represent. Pluripotent stem cells can be taken through the developmental steps that establish organs during embryogenesis.
Rebecca Heald, Ph.D. University of California, Berkeley
(This will be a hybrid lecture, in person at Lipsett Amphitheater and on NIH VideoCast.) The scientific goal of my laboratory is to elucidate the molecular mechanisms of cell division and size control. Our interdisciplinary approaches take advantage of in vitro systems, particularly cytoplasmic extracts prepared from eggs of the frog Xenopus laevis that reconstitute mitotic chromosome condensation and spindle assembly in vitro.
(This will be a hybrid lecture, in person at Lipsett Amphitheather and on NIH VideoCast.) Antiretroviral therapy has markedly reduced morbidity and mortality for persons living with human immunodeficiency virus (HIV). Individual tailoring of antiretroviral regimens has the potential to further improve the long-term management of HIV through the mitigation of treatment failure and drug-induced toxicities.
John Kuriyan, Ph.D. University of California, Berkeley
(This will be a hybrid lecture, in person at Lipsett Amphitheather and on NIH VideoCast.) Dr. Kuriyan’s research concerns the atomic-level structure and mechanism of the enzymes and molecular switches that carry out cellular signal transduction. His laboratory uses x-ray crystallography to determine the three-dimensional structures of proteins involved in signaling, as well as biochemical, biophysical, and cell biological analyses to elucidate mechanisms.
Whether older individuals with diabetes and obesity should be encouraged to lose weight remains controversial. Observational studies have suggested that weight loss in older adults may be associated with increased risk of mortality, but this conclusion may be due to unintentional weight loss. A randomized trial in which some individuals are assigned to a weight loss program is the best way to address the question of whether intentional efforts to lose weight are appropriate for older individuals who have diabetes and obesity.
(This will be a hybrid lecture, in person at Lipsett Amphitheather and on NIH VideoCast.) Breast cancer is the most common cancer in women, with an estimated 2.3 million new cases diagnosed in 2021 worldwide. Geographic variations in age specific incidence and mortality point to differences in etiology. Decades after discovery, the estrogen receptor remains the single most important determinant of outcomes in breast cancer but innovative and precise biology-driven approaches to therapy are being integrated into clinical practice.
The Fair laboratory focuses on mechanisms and principles that underlie the developing brain. The majority of this work uses functional MRI and resting state functional connectivity MRI to assess typical and atypical populations. Dr. Fair is the co-director of the new Masonic Institute for the Developing Brain.
(This will be a hybrid lecture, on Tuesday, in person at Lipsett Amphitheather and on NIH VideoCast.) Neurons employ many mechanisms to sustain function throughout lifetime. Following traumatic injury to axons, neurons often initiate complex responses to regenerate and repair. To understand the underlying mechanisms, we established in vivo laser axotomy assay in C. elegans. Using live imaging, we characterized rapid cellular dynamics following axon injury. We carried out large-scale genetic screening and discovered several molecular pathways.
This page was last updated on Thursday, November 18, 2021
