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      • Nina F. Schor, M.D., Ph.D.
      • Roland A. Owens, Ph.D.
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      • The NIH Research Festival is the showcase for intramural research
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  • IRP Website
    • A premier environment where creative scientists conduct fundamental research for the betterment of human health – we are the IRP
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  • The NIH Catalyst
    • A publication for and about the NIH intramural research community
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  • NIDB
    • The NIH Intramural Database collects and disseminates information about research being performed in the Intramural Programs
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2023–2024

WALS 2023–2024 season poster

Thymic Mimetic Cells: Tolerogenic Masqueraders

Diane Mathis, Ph.D.
Harvard Medical School
Wednesday, September 13, 2023 at 2 p.m. ET
William E. Paul Lecture

Autoimmunity results from a breakdown in one or more central or peripheral mechanisms of lymphocyte tolerance induction or maintenance. In the case of T cells, central tolerance is imposed within the thymus, key orchestrators being medullary thymic epithelial cells (mTECs), which play critical roles in both negative selection of T effector cells and positive selection of T regulatory cells. A unique feature of mTECs is expression of thousands of loci encoding antigens typically associated with fully differentiated peripheral parenchymal cells (peripheral-tissue antigens or PTAs).

Prospective Cohort Studies for Environmental Health Research

Dale Sandler, Ph.D.
NIEHS, NIH
Wednesday, September 20, 2023 at 2 p.m. ET
G. Burroughs Mider Lecture

In this lecture, Dr. Sandler will describe the wide range of research made possible by the Sister Study cohort established in 2003 to study environmental and genetic risk factors for breast cancer in a cohort of 50,000 women who have a sister with breast cancer. The prospective design and extensive questionnaire data, biological samples, and physiologic measurements at enrollment along with detailed follow-up questionnaires has allowed researchers to study lifecourse exposures associated with breast cancer as well other health endpoints.

The Aldehyde Hypothesis

Heran Darwin, Ph.D.
NYU Langone Health, Grossman School of Medicine
Wednesday, September 27, 2023 at 2 p.m. ET

Mycobacterium tuberculosis, a human-exclusive pathogen, is arguably the deadliest microbe on the planet. While SARS-CoV-2 killed more people than M. tuberculosis for a year or two, it is estimated M. tuberculosis has killed 1-2 million people yearly for millennia. The long coexistence of this bacterial species with humans has likely resulted in the selection of host and pathogen populations that prevent either's extinction. We propose that reactive aldehydes produced in metabolic pathways are exploited during certain microbial infections.

The Dark Side of DNA: How the Immune System Senses DNA as a Danger Signal

Zhijian "James" Chen, Ph.D.
University of Texas Southwestern Medical Center
Wednesday, October 18, 2023 at 2 p.m. ET

https://videocast.nih.gov/watch=51169

The World of Insect-Bacterial Symbiosis: What We Have and Have Not Learned

Nancy Moran, Ph.D.
University of Texas at Austin
Wednesday, October 25, 2023 at 2 p.m. ET

 https://videocast.nih.gov/watch=51171

Sleuthing the Microbiome Reveals Undercover Agents of Oncogenesis

Cynthia L Sears, M.D.
Johns Hopkins University School of Medicine
Wednesday, November 1, 2023 at 2 p.m. ET
Astute Clinician Lecture

Each human microbe reveals to us a story about health or disease, guided by its individual potential and community interaction. This Astute Clinician Lecture will provide context for microbe promotion of colon carcinogenesis as illustrated by two vignettes, one defined by a single bacterial gene and a second revealing community potential to mold disease.

Objectives: 

1. To inform on microbial promotion of human colon cancer.

2. To illustrate the potential of individual bacterial contributors to human colon cancer pathogenesis.

The Great Escape: Phage Lysis and Its Control

Ryland Young, Ph.D.
Texas A&M, Department of Biochemistry & Biophysics
Wednesday, November 8, 2023 at 2 p.m. ET
DeWitt Stetten Jr. Lecture

https://videocast.nih.gov/watch=51120

Hearing Loss and Dementia: From Epidemiological Insights to the ACHIEVE Trial and Public Policy in the U.S.

Frank Lin, M.D., Ph.D.
Johns Hopkins Medicine, Bloomberg School of Public Health
Wednesday, November 15, 2023 at 2 p.m. ET

https://videocast.nih.gov/watch=51173

The Neurobiology and Evolution of Vocal Learning and Spoken Language

Erich D. Jarvis, Ph.D.
The Rockefeller University
Wednesday, November 29, 2023 at 2 p.m. ET
Marshall W. Nirenberg Lecture

https://videocast.nih.gov/watch=52199

Neuron–Glial Interactions Health and Disease: From Cognition to Cancer

Michelle Monje, M.D., Ph.D.
Stanford Medicine
Wednesday, January 10, 2024 at 2 p.m. ET

** Remote only** 

https://videocast.nih.gov/watch=51182

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This page was last updated on Monday, November 18, 2024

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    • Browse by Season
    • Browse by Speaker
  • Named & Honorific Lectures
    • NIH Director’s Lecture
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    • G. Burroughs Mider Lecture
    • Marshall W. Nirenberg Lecture
    • Margaret Pittman Lecture
    • J. Edward Rall Cultural Lecture
    • Astute Clinician Lecture
    • Robert S. Gordon Jr. Lecture
    • George Khoury Lecture
    • Florence Mahoney Lecture on Aging
    • William E. Paul Lecture
    • DeWitt Stetten Jr. Lecture
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WALS 2024–2025 WALS Season season poster

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  • About OIR
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  • Sourcebook
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    • Visit Website
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    • Visit Website
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